Agenda 190115 PhD defense Niels ter Huurne

Niels ter Huurne ADHD and the Alpha Rhythm. On the role of alpha oscillations in neural mechanisms underlying Attention-deficit Hyperactivity Disorder

Attention deficit hyperactivity disorder is behaviorally classified by having problems regulating attention (inattentiveness) and problems regulating motor actions (impulsivity and hyperactivity.

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Niels ter Huurne ADHD and the Alpha Rhythm. On the role of alpha oscillations in neural mechanisms underlying Attention-deficit Hyperactivity Disorder

Attention deficit hyperactivity disorder is behaviorally classified by having problems regulating attention (inattentiveness) and problems regulating motor actions (impulsivity and hyperactivity. The underlying pathophysiology of ADHD is far from clear, and is characterized by a heterogeneous pattern of structural and functional brain abnormalities, but theories on electrophysiological contributions are relatively underdeveloped. Ter Huurne explored a putative role for aberrant modulation of alpha oscillatory activity in ADHD, as alpha oscillations are crucial in inhibiting activity of task-irrelevant functional brain areas. Both in the attention domain and in the motor domain he found atypical and decreased modulation of alpha, with relatively low alpha activity in task-irrelevant brain areas. Reduced alpha activity was shown to be predictive of higher scores on ADHD reports. Ter Huurne concludes that failing modulation of alpha oscillation contributes to neural mechanisms underlying ADHD. These findings could result in the development of alpha as a biomarker for ADHD, promoting a biological classification approach of ADHD. Furthermore, it could contribute to improving and developing therapeutic interventions targeting alfa, like pharmaceutical and neurofeedback approaches.

PhD thesis: ADHD and the Alpha Rhythm. On the role of alpha oscillations in neural mechanisms underlying Attention-deficit Hyperactivity Disorder

Date, time and location PhD defense

  • Date: 15 January 2019
  • Time: 12.30 hrs
  • Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2

Biography

Niels ter Huurne (1978) studied Medicine at Radboud University. After obtaining his medical degree in 2006 he specialized in child and youth psychiatry.

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Biography

Niels ter Huurne (1978) studied Medicine at Radboud University. After obtaining his medical degree in 2006 he specialized in child and youth psychiatry. The research in this thesis was performed at the department of Psychiatry of Radboud university medical center, at the Donders Center for Medical Neuroscience. Currently, he works as a psychiatrist at Karakter (kinder- en jeugdpsychiatrie) and the OG Heldringstichting (Jeugdzorgplus).


Promotor

  • Promotors: Prof. J.K. Buitelaar and prof. O. Jensen

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