Martijn Selten Disruption of inhibitory brain cells is an important factor in autism and schizophrenia
Disruption of brain development has been identified as a key player in the development of neurodevelopmental disorders such as autism or schizophrenia.read more
Martijn Selten Disruption of inhibitory brain cells is an important factor in autism and schizophreniaDisruption of brain development has been identified as a key player in the development of neurodevelopmental disorders such as autism or schizophrenia. Mutations in the DNA of patients are often an important reason for disrupted development. In this thesis we studied animal models of different neurodevelopmental disorders. We investigated if there are similarities in the nature of the disrupted brain development between these models. Our research shows that all studied models show a disrupted function of a specific class of brain cells, the inhibitory cells. These cells regulate the way the brain processes information, and a disrupted function of these cells leads to problems in information processing. The results presented in this thesis underline the importance of the proper functioning of the inhibitory system, and point towards inhibitory brain cells as a therapeutic target. Eventually, developing therapeutic strategies targeting these cells could lead to new treatments for autism or schizophrenia.
PhD thesis: Altered function of the inhibitory system in rodent models of neurodevelopmental disorders
Date, time and location PhD defense
- Date: 21 January 2019
- Time: 14.30 hrs
- Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2
Martijn Selten (1987) graduated in 2011 from Radboud University (Master of Medical Biology). He carried out the above doctoral research at the Department of Cognitive Neuroscience of the Radboudumc, within the Donders Institute. Currently, he works as a postdoctoral researcher at King’s College London where he continues his research on the role of inhibitory neurons in neurodevelopmental disorders.
- Promotor: Prof. J.H.L.M. van Bokhoven
- Co-promotors: N. Nadif Kasri PhD and S.M. Kolk PhD