Peter-Bram 't HoenPerson-oriented and innovative” is Radboudumc’s slogan. Every patient is unique and has his own story. This asks for a person-oriented treatment. The large-scale molecular and clinical data available for a patient may tell part of this personal story. However, the story told by these ‘big data’ is complex and not understood without advanced computer analyses. As professor of Bioinformatics, I would like to focus on the development of analysis methods for data that can be used for the development of personalized therapeutics. In my lecture, I will sketch the potential and the challenges of the personalized medicine approach based on my personal experiences as a scientific researcher.
Peter-Bram ‘t Hoen, professor of Bioinformatics with a focus on Personalized Medicine, and head of the Centre for Molecular and Biomolecular Informatics (CMBI).
His main research interest is the impact of genetic variants on transcription, mRNA processing, translation and clinical phenotypes.
Date, time and location Inaugural lecture Peter-Bram 't Hoen
- Date: 5 April 2019
- Time: 15:45 hrs
- Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2
Prof.dr. Peter-Bram ’t Hoen obtained his Master degrees in Biochemistry and Pharmacochemistry cum laude from the Vrije Universiteit Amsterdam. In 2002, he received his PhD degree from Leiden University. His PhD thesis was entitled “Modulating the activity of biotransformation enzymes. Studies with antisense oligonucleotides and enzyme inhibitors.” From 2002 until 2009, he was postdoctoral researcher in Leiden University Medical Center’s department of Human Genetics, investigating disease mechanisms, biomarkers and antisense therapies for Duchenne Muscular Dystrophy. From 2010 until 2018 he headed the Bioinformatics research group in the same department, as an assistant and associate professor, focusing on the analysis and integration of high-dimensional molecular data. He started in February 2018 as full professor of Bioinformatics at Radboud University Medical Center Nijmegen and head of the Centre for Molecular and Biomolecular Informatics (CMBI). ’t Hoen leads the data analysis, integration and stewardship pillar in X-omics, one of the large national research infrastructures. He is member of the executive committee of the RD-Connect community fostering data sharing and integration for rare diseases. ‘t Hoen is active in the European Joint Programme on Rare Diseases and board member of the research working group European Reference Network on neuromuscular diseases (EURO-NMD). He is also co-leading the Personal Health Train coalition, developing a data infrastructure to advance healthcare and biomedical science through interoperable and federated data management. He has published >150 papers in peer-reviewed scientific journals.