Sanne van Lith How to kill cancer; starve it and shoot it
This thesis describes how cancer cells can adapt their metabolism in order to maintain fast growth.read more
Sanne van Lith How to kill cancer; starve it and shoot itThis thesis describes how cancer cells can adapt their metabolism in order to maintain fast growth. We show how we can inhibit this adapted metabolism, and thereby starve the tumor cell. In the second part of this thesis we make use of so-called nanobodies, small proteins derived from llama antibodies. We use nanobodies that bind specifically to tumor cells, and we investigate mechanisms to conjugate therapeutic groups to these nanobodies, so they can be used for tumor therapy. One example of a therapeutic group is a photosensitizer, which can be used for photodynamic therapy. When this photosensitizer is activated with light of a specific wavelength, it is able to shoot the tumor cell to which it is bound. In the future, the strategies of starving and shooting a tumor cell could possibly be combined.
Date, time and location PhD defense
- Date: 28 Augustus 2019
- Time: 14:30 hrs
- Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2
Sanne van Lith (1988) obtained her Master’s degree in Biomedical Sciences (cum laude) at the Radboud University in 2012. She performed her PhD research at the department of Pathology at the Radboud university medical center. Currently, Sanne is working as a postdoc researcher at the department of Radiology and Nuclear Medicine at the Radboud university medical center.
- Promotors: Prof. R.E. Brock and Prof. P. Wesseling
- Co-promotor: W.P.J. Leenders PhD