Judith van den Brule Cerebral hemodynamics. After cardiac arrest, in sepsis and in the human endotoxemia model
In this thesis we studied cerebral hemodynamics in patients with an inflammatory status, more specifically patients after cardiac arrest and patients with sepsis.read more
Judith van den Brule Cerebral hemodynamics. After cardiac arrest, in sepsis and in the human endotoxemia modelIn this thesis we studied cerebral hemodynamics in patients with an inflammatory status, more specifically patients after cardiac arrest and patients with sepsis. Cerebral autoregulation may be disturbed after cardiac arrest and to determine this autoregulation accurately sufficient blood pressure variability (eventually induced) is necessary. The cerebral perfusion pressure must also be maintained at a sufficiently high level to prevent secondary brain damage. In addition, the lack of recovery to a normal cerebrovascular profile is a predictor of poor outcome.
The cerebral autoregulation may also be impaired in sepsis. The human endotoxemia model is used to mimic sepsis, but this model cannot simply be used for sepsis-related cerebrovascular research. An important clinical implication is that titration of the systemic circulation to a specific minimum blood pressure by vasopressors will not automatically restore cerebral perfusion in patients with sepsis.
Future research should lead to optimal, individual cerebral perfusion.
Date, time and location PhD defense
- Date: 21 February 2019
- Time: 12.30 hrs
- Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2
BiographyJudith van den Brule graduated in 2002 with the highest distinction at the Katholieke Universiteit Leuven. She was then trained as a cardiologist with thereafter a fellowship intensive care in the Radboud university medical center. Since 2010 she has been working as a cardiologist-intensivist in the Radboudumc. The research in this thesis was performed at the department of Intensive Care of the Radboud university medical center, within the Radboud Institute for Health Sciences.
- Promotor(s): Prof. J.G. van der Hoeven
- Co-promotor(s): Dr C.W.E. Hoedemaekers