Mirjam Pijl Autism in infancy and toddlerhood. Investigating infants at risk and enhancing early detection and intervention

Autism in infancy and toddlerhood. Investigating infants at risk and enhancing early detection and intervention
Agenda 26Jun2019 PhD defense Anke van Erp

Mirjam Pijl Targeted treatment options for young sarcoma patients

Sarcoma are highly malignant, rare tumors and have a relatively high incidence in children, adolescents and young adults. Current treatment options have not significantly increased survival rates over the last decades.

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Mirjam Pijl Targeted treatment options for young sarcoma patients

Sarcoma are highly malignant, rare tumors and have a relatively high incidence in children, adolescents and young adults. Current treatment options have not significantly increased survival rates over the last decades. Patients with metastatic disease have an even worse survival rate compared to patients with localized disease. In addition, they have limited treatment options. My thesis focuses on preclinical research into new targeted treatment options for young patients with rhabdomyosarcoma, Ewing sarcoma and desmoplastic small round cell tumors. My research has shown, via the use of sarcoma tumor models, that targeted therapies directed against so-called tyrosine kinases and the DNA repair protein PARP1 can reduce rhabdomyosarcoma, Ewing sarcoma and desmoplastic small round cell tumor cell growth. In addition, we showed that proteins involved in the evasion of the destructive capacities of the immune system are present in the clinically-derived tumor material of young sarcoma patients.

Date, time and location PhD defense

  • Date: 26 June 2019
  • Time: 12.30 hrs
  • Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2

Promotor

  • Promotor(s): Prof. Winette T.A. van der Graaf
  • Co-promotor(s): Yvonne M.H. Versleijen-Jonkers PhD and Emmy D.G. Fleuren PhD