Roos Schellevis The genetics of central serous chorioretinopathy
Central serous chorioretinopathy (CSC) is an eye disease characterized by fluid accumulation between the layers of the retina leading to loss of vision.read more
Roos Schellevis The genetics of central serous chorioretinopathyCentral serous chorioretinopathy (CSC) is an eye disease characterized by fluid accumulation between the layers of the retina leading to loss of vision. The treatment options for CSC are limited because the cause of the disorder is currently unknown.
During her research Roos Schellevis investigated genetic variations in patients with CSC to find the cause of the disease. First she looked at changes in genes that are thought to be related to CSC. Next, she compared the complete DNA of patients suffering from CSC with healthy volunteers to identify new genetic variations causing the disease. Schellevis also looked at families in which CSC occurs to find changes in the DNA that might underlie familial CSC. She discovered various mechanisms that might explain CSC, such as variations in the complement system (part of the immune system) and hormone regulation. The role of these specific genetic variations in the emergence of CSC needs to be further explored in order to accelerate the development of new therapies that interfere with these mechanisms.
Date, time and location PhD defense
- Date: 1 March 2019
- Time: 10.30 hrs
- Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2
About the PhD Candidate Roos Schellevis
Roos Schellevis (1991) graduated with first-class honors from the Radboud University in 2014 (Master’s degree in Molecular Life Sciences). During her PhD she worked at the department of Ophthalmology of the Radboudumc, affiliated with the Donders Institute. Here she investigated the genetic causes of central serous chorioretinopathy.
- Promotor(s): Prof. A.I. den Hollander
- Co-promotor(s): E.K. de Jong PhD