Karijn Pijnenburg-Kleizen Congenital adrenal hyperplasia: clinical and biochemical consequences of elevated adrenal steroid precursors.

Congenital adrenal hyperplasia (CAH) is a congenital disorder, in which the production of hormones in the adrenal gland is disturbed. The stress hormone and the salt hormone are not produced enough, while too many adrenal androgens are formed. Also, several steroid precursors accumulate.
In this thesis we study the factors that influence growth in children with CAH. We show that the treatment strategie should be different in childhood than in puberty, to ensure the best outcomes in the long term. Also, based on cellstudies we show that the steroid precursors that accumulate in CAH patients might partially compensate their stress hormone deficiency.
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Agenda 21mar2019 PhD defense Karijn Pijnenburg-Kleizen

Karijn Pijnenburg-Kleizen Congenital adrenal hyperplasia: clinical and biochemical consequences of elevated adrenal steroid precursors.

Congenital adrenal hyperplasia (CAH) is a congenital disorder, in which the production of hormones in the adrenal gland is disturbed.

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Date, time and location PhD defense

  • Date: 20 March 2019
  • Time: 16:30 hrs
  • Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2

About the PhD Candidate

Karijn Pijnenburg-Kleizen (1983) obtained her medical degree with honors in 2007, at the Radboud university medical center.

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About the PhD Candidate

Karijn Pijnenburg-Kleizen (1983) obtained her medical degree with honors in 2007, at the Radboud university medical center. In 2014 she finished her pediatric training. During this residency, she started the research for her thesis. Currently she is a clinical fellow in pediatric endocrinology at the Amalia children’s hospital, Radboud university medical center. She will finish this fellowship in 2019.
 

Promotor

  • Promotor(s): Prof. C. Noordam and Prof. C.G.J. Sweep
  • Co-promotor(s): H.L. Claahsen - van der Grinten, PhD and P.N. Span, PhD

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