About this Radboud Research Round PlusDespite cellular immunotherapies being live cell products, which have the potential to be curative but can also cause severe side effects, only little is known about their in vivo distribution, fate and function both preclinically and clinically. One focus of my team is to use multi-modal imaging to elucidate the behaviour of cellular therapeutics in vivo. I will present data from our recent T‑cell therapy tracking studies in solid tumours including various methodological aspects as well as some tracking surprises.
About the speaker: Gilbert FruhwirthExcited by the fundamental molecular processes governing physiology and pathophysiology, Gilbert Fruhwirth studied Chemistry with a focus on Biochemistry and Biotechnology at Graz University of Technology in Austria. Subsequently, he embarked on a PhD in Biochemistry and Cell Biology at the same institution, from which he graduated in 2005. At that time his research experience spanned biophysical chemistry as well as biochemistry and cell biology, and he went abroad to seek new challenges in studying whole organisms. Enthralled by cell motility, he moved as a post-doc to Prof Ng’s lab at the Randall Division/King's College London, and later joined the Comprehensive Cancer Imaging Centre at King’s College London & UCL. He studied protein-protein interactions in metastatic cancer cells and the consequences of chemokine receptor mutations in cancer metastasis. Furthermore, he developed intravital FRET/FLIM imaging technologies and used multi-modal imaging (PET/SPECT-CT-Optical) to shed light on the same processes in live animals. In 2013, he was appointed Lecturer in Imaging Biology at what is now the School of Biomedical Engineering and Imaging Sciences at King’s College London. This position enabled him to develop his own independent research programme within an environment spanning basic and clinical science. In 2016, he obtained tenure and in summer 2018 he was promoted to Senior Lecturer in Imaging Biology.
9 May 2019, 16:00 - 17:30 hrs.
Tuinzaal, route 706