Roeland Wasmann Antifungal pharmacokinetics in the era of the obesity pandemic
In recent decades we have seen an enormous increase in obesity with far-reaching consequences for global health.read more
Roeland Wasmann Antifungal pharmacokinetics in the era of the obesity pandemicIn recent decades we have seen an enormous increase in obesity with far-reaching consequences for global health. In the hospital we see more and more obese patients with life-threatening diseases. Examples of these life-threatening diseases are fungal infections with an estimated annual death toll of more than 1.5 million people. The treatment of these infections requires long-term intake of medication that must be dosed very precisely. In obese patients, however, we do not know how to dose these drugs. Often this leads to improper treatment with an increasing risk of death. Sometimes it can also lead to more side effects, so that treatment cannot be continued. In this dissertation the researchers were able to formulate dosage recommendations for the four most important antifungal agents. Adjustment of the standard dosage was necessary for all four products. With their study, the researchers have made a unique contribution to improving the knowledge in the field of treatment of (extremely) overweight patients.
Date, time and location PhD defense
- Date: 15 November 2019
- Time: 12.30 hrs
- Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2
Roeland Wasmann studied pharmacy at the University of Groningen and obtained his degree in 2013. He carried out the above doctoral research at the department of Pharmacy at the Radboudumc, within the Radboud Institute for Health Sciences (RIHS). Currently, Roeland is a postdoctoral fellow at the Division of Clinical Pharmacology of the University of Cape Town with a focus on the treatment of pediatric patients with pneumonia.
- Promotors: prof. D.M. Burger and prof. C.A.J. Knibbe
- Co-promotor: R.J.M. Bruggemann