Amanda Jager Cognitive control of aggressive behavior
In this thesis, Amanda has investigated, by using an animal model, how someone could lose cognitive control and starts to behave aggressively.read more
Amanda Jager Cognitive control of aggressive behaviorAggression and violence have always been a burden to public health. Over a million people lose their lives because of violence each year, making it one of the leading causes of death worldwide for middle aged people. Aggressive behavior is a common symptom in several neuropsychiatric disorders such as psychopathy or ADHD. In this thesis, Amanda has investigated, by using an animal model, how someone could lose cognitive control and starts to behave aggressively. Reduced inhibition in brain regions, involved in the regulation of emotional responses, seems to play a role in the occurrence of aggression. Besides that, factors such as insensitivity to negative feedback and difficulties with unlearning behavior seem to be involved. A low dose of methylphenidate reduced aggression and anxiety, while a high dose increased aggression. Aggression observed in neuropsychiatric disorders may be a consequence of heightened anxiety in combination with a deficit in attention processing.
Date, time and location PhD defense
- Date: 18 November 2019
- Time: 18.30 hrs
- Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2
Amanda Jager (1989) obtained her master’s degree in Neurosciences at the VU University Amsterdam in 2013. The research in this thesis was performed at the department of Cognitive Neuroscience (at the Radboudumc and the Donders Institute for Brain, Cognition and Behaviour (DCMN)) and the department of Anatomy (at the Radboudumc). Currently, Amanda guides students as a study adviser at the Wageningen University & Research.
- Promotors: prof. D.D.M. Braat and prof. L.T. Kozicz
- Co-promotors: A.W. Nap PhD and J.M. Oosterman PhD