Anneleen Berende Persistent symptoms attributed to Lyme disease and their antibiotic treatment. Results from the PLEASE study
This thesis gives more insight into persistent symptoms attributed to Lyme disease and the effect of antibiotic treatment on these symptoms.read more
Anneleen Berende Persistent symptoms attributed to Lyme disease and their antibiotic treatment. Results from the PLEASE studyLyme disease is caused by the bacterium Borrelia burgdorferi, that can infect the skin, joints, or the central nervous system. Most patients with manifestations of Lyme disease are successfully treated with antibiotics. However, regardless of initial appropriate treatment, persistent symptoms may arise, such as fatigue, arthralgia, or cognitive problems. There is still much unclear about these persistent symptoms that are attributed to Lyme disease, also called post–Lyme disease syndrome. For example, the characteristics associated with persistent symptoms are yet unknown. Furthermore, their treatment remains controversial. This thesis gives more insight into persistent symptoms attributed to Lyme disease and the effect of antibiotic treatment on these symptoms. The research in this thesis shows that 14 weeks of antibiotics gives no additional clinical improvement over 2 weeks of antibiotics in patients with persistent symptoms attributed to Lyme disease.
Date, time and location PhD defense
- Date: 25 November 2019
- Time: 16.30 hrs
- Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2
Anneleen Berende (1979) graduated from Radboud University (master's degree in Biomedical Health Sciences in 2001 and Medical degree in 2006). She carried out the described doctoral research at the Department of Internal Medicine of the Radboudumc, within the Radboud Institute for Health Sciences (RIHS). She combined her research with her residency program in Internal Medicine at Radboudumc. She is currently working as internist in Amphia hospital, Breda.
- Promotors: prof. B.J. Kullberg and prof. A.W.M. Evers
- Co-promotors: H.J.M. ter Hofstede PhD and H. van Middendorp PhD