Tanja Dekkers Challenging aspects of Primary Aldosteronism
In primary aldosteronism (PA) autonomous secretion of the hormone aldosterone by one or both adrenal glands induces high blood pressure and sometimes low potassium levels.read more
Tanja Dekkers Challenging aspects of Primary AldosteronismIn primary aldosteronism (PA) autonomous secretion of the hormone aldosterone by one or both adrenal glands induces high blood pressure and sometimes low potassium levels. PA is a frequent cause of hypertension (5-10% of hypertensive patients). In most cases, PA is caused by either a one-sided aldosterone-producing adrenal lump (adenoma) or by bilateral adrenal enlargement (hyperplasia). Distinction between the two is crucial, because the former is treated surgically and the latter medically. In this thesis, the researchers discuss three aspects of PA: 1) Prevalence: it is demonstrated that the reported PA prevalence in the literature is mostly the result of study design en diagnostic work-up. 2) Subtyping: in an outcome-based, randomized diagnostic trial it is shown that adrenal vein sampling is not always superior to CT-scan to one-sided adrenal adenoma from two-sided hyperplasia. 3) Histology: based on pathology reports, the researchers question the assumed dichotomy between one-sided adenoma and two-sided hyperplasia.
Date, time and location PhD defense
- Date: 26 November 2019
- Time: 14.30 hrs
- Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2
Tanja Dekkers (1984) obtained her medical degree at the Radboudumc in 2010. The research in this thesis was performed at the department of Internal Medicine of the Radboudumc. Currently, Tanja is a fellow at the department of Vascular Medicine of this hospital. Within the upcoming year she hopes to complete her fellowship.
- Promotors: prof. J.W.M. Lenders, prof. G.J. van der Wilt and prof. L.J. Schultze Kool
- Co-promotor: J. Deinum PhD