Dylan Henssen Trigeminal neuroanatomy and the subsequent insights in treating chronic neuropathic orofacial pain with motor cortex stimulation
This thesis focussed on the anatomy of the trigeminal nerve and contributed to improved treatment of orofacial pain using an electric mesh on the brain.read more
Dylan Henssen Trigeminal neuroanatomy and the subsequent insights in treating chronic neuropathic orofacial pain with motor cortex stimulationPatients suffering from intractable pain often turn to experimental treatments which need to be evaluated scientifically. This thesis contributes to this and evaluated the effectiveness of one of these experimental procedures: motor cortex stimulation (MCS). For MCS, a neurosurgeon places a small electronic mesh on the surface of the brain to send in signals that are thought to disturb the pain signaling pathways. These signals can provide significant pain relief in a well-characterized group of patients suffering from chronic orofacial pain according to this thesis. To explain why another group of patients suffering from chronic orofacial pain do not respond favorable, the researchers turned to anatomical knowledge. They found that a never discovered brain pathway connects two brain areas which are important in the processing of pain from the orofacial region. Based on these insights, the researchers provided patients with another experimental neuromodulation strategy, obtaining significant pain relief in patients which were considered non-responders to MCS.
Thesis title: Trigeminal neuroanatomy and the subsequent insights in treating chronic neuropathic orofacial pain with motor cortex stimulation
Date, time and location PhD defense
- Date: 11 October 2019
- Time: 12.30 hrs
- Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2
Dylan Henssen (1993) obtained his medical degree in 2018. In 2016, during his Master, he started as a PhD student at Radboud university medical center/Donders Institute for Brain, Cognition and Behaviour. Currently, Dylan is a resident in training and postdoctoral researcher at the Radiology and Nuclear Medicine department combining his passions for science, education and clinical care.
- Promotor(s): prof. T. Kozicz PhD & prof. R. Bartels PhD
- Co-promotor(s): A.M. van Cappellen van Walsum PhD & R. van Dongen PhD