Agenda 15oct2019 PhD defense Lotte Mousset

Lotte Mousset Improvement of T cell Functionality in Cancer Immunotherapy: Time to AKT

In this thesis, various strategies that could possibly be applied to improve T cell immunotherapy for the treatment of cancer are described.

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Lotte Mousset Improvement of T cell Functionality in Cancer Immunotherapy: Time to AKT

In this thesis, various strategies that could possibly be applied to improve T cell immunotherapy for the treatment of cancer are described. AKT inhibition has proven to be a powerful tool for generating CD8+ and CD4+ T cells with stem cell memory characteristics in the lab. A shift in the T helper population and reduced CD8+ T cell functionality in the presence of AKT-inhibited CD4+ T cells, shows that AKT inhibition may be best applied in the absence of CD4+ T cells. We discovered that CD8+ T cells from early memory can be retained when AKT inhibition and specific T cell vaccination are combined. In addition, we have demonstrated that local reduction of PD-L1 expression on tumor cells provides greater anti-tumor T cell responses. Together, both temporary AKT inhibition to improve CD8+ T cell functionality and lifespan, and reduction in PD-L1 offer two different and possibly complementary strategies to improve T cell immunotherapy for cancer treatment.

Thesis titel: Improvement of T cell Functionality in Cancer Immunotherapy: Time to AKT

Date, time and location PhD defense

  • Date: 15 October 2019
  • Time: 12.30 hrs
  • Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2

Biography

Charlotte Mousset (1989) obtained her master's degree in Biomedical Sciences at the University of Amsterdam in 2015.

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Biography

Charlotte Mousset (1989) obtained her master's degree in Biomedical Sciences at the University of Amsterdam in 2015. The research for this thesis was performed at the Department of Laboratory Medicine - Laboratory Hematology at the Radboud university medical center, within the Radboud Institute for Molecular Sciences (RIMLS). Charlotte will continue her research on immunotherapy as a postdoctoral fellow at the National Cancer Institute/National Institutes of Health in the USA.


Promotor

  • Promotor(s): prof. J.J.H. Jansen PhD
  • Copromotor(s): H. Dolstra PhD & A.B. van der Waart PhD

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