Agenda 18oct2019 PhD defense Liz van Erp

Liz van Erp The role of maternal antibodies in RSV infection. Emphasis on functionality and implications in disease

A better understanding of the broad spectrum of antibody functionalities during an RSV infection and ways to test these functionalities are needed to assess new vaccines. During this PhD project, multiple tests are developed that will contribute to this understanding.

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Liz van Erp The role of maternal antibodies in RSV infection. Emphasis on functionality and implications in disease

The respiratory syncytial virus (RSV) is a leading global cause of respiratory disease in infants. In most individuals, RSV infection only leads to a common cold. However, in some cases, RSV can cause bronchiolitis and viral pneumonia, a result of excessive inflammation in the lower airways. However, no vaccines or antiviral therapies are currently available. Development of a vaccine against RSV is difficult, as it is currently unknown why only a small portion of the RSV-infected infants experiences excessive disease. The research that is performed during this PhD project shows that antibodies that are naturally present in young infants can show decreased functionality, which can lead to severe disease. A better understanding of the broad spectrum of antibody functionalities during an RSV infection and ways to test these functionalities are needed to assess new vaccines. During this PhD project, multiple tests are developed that will contribute to this understanding.

Thesis title: The role of maternal antibodies in RSV infection. Emphasis on functionality and implications in disease

Date, time and location PhD defense

  • Date: 18 October 2019
  • Time: 10.30 hrs
  • Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2

Biography

Elisabeth Anna (Liz) van Erp (1990) studied Biomedical Sciences at Utrecht University, where she graduated with first-class honors in 2015 (master’s degree in Infection and Immunity).

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Biography

Elisabeth Anna (Liz) van Erp (1990) studied Biomedical Sciences at Utrecht University, where she graduated with first-class honors in 2015 (master’s degree in Infection and Immunity). The abovementioned doctoral research was carried out at the Dutch Institute for Public Health (RIVM) in Bilthoven, in collaboration with the Radboud Institute for Molecular Life Sciences (RIMLS) of the Radboud university medical center.
 


Promotor

  • Promotor(s): prof. R. de Groot PhD & prof. D. van Baarle PhD
  • Copromotor(s): P. van Kasteren PhD & G. Ferwerda PhD

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