Peter Janke Innovative Biomaterials for Ureter Reconstruction and Urinary Diversion
Repairing ureteral defects (e.g. after a trauma) or urinary diversion (e.g. after the removal of the bladder due to bladder cancer) is challenging. The aim of this thesis was the development of innovative hybrid biomaterials which can be used as prostheses for regeneration of genitourinary tissue.read more
Peter Janke Innovative Biomaterials for Ureter Reconstruction and Urinary DiversionRepairing ureteral defects (e.g. after a trauma) or urinary diversion (e.g. after the removal of the bladder due to bladder cancer) is challenging. There is a lack of suitable donor tissue. The aim of this thesis was the development of innovative hybrid biomaterials which can be used as prostheses for regeneration of genitourinary tissue. In a first step, supportive stent-like synthetic biomaterials were developed. These synthetic biomaterials were combined with natural biomaterials such as collagen to form hybrid tubular prosthesis combing both, strength and guided tissue regeneration. Subsequently, these hybrids were labelled with a non-toxic MRI contrast agent allowing real-time monitoring of such a prosthesis upon implantation. Furthermore, this thesis showed that the type of sterilization (e.g. y-sterilization, EtO degassing) heavily influences the performance of hybrid biomaterials and thus, tissue regeneration. Imageable hybrid biomaterials as well as the choice of sterilization may aid in the development of patient specific prostheses.
Thesis title: Innovative Hybrid Tools for Ureter Reconstruction and Urinary Diversion: Insights in Scaffold Design, (Bio)mechanical Properties, Tissue Remodeling and Noninvasive Monitoring by MRI
Date, time and location PhD defense
- Date: 18 October 2019
- Time: 12.30 hrs
- Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2
Heinz Peter Janke (1984) graduated in 2013 from the FH Aachen University of Applied Sciences (Master in Biomedical Engineering). He carried out the described doctoral research at the Department of Urology of the Radboud university medical center, within the Radboud Institute for Molecular Life Sciences (RIMLS). Peter is currently working for the Police Department Neuss (Germany) as a crime scene investigator.
- Promotor(s): prof. W. Feitz PhD
- Copromotor(s): E. Oosterwijk PhD