Karina Grooteman Disease characterization and treatment of gastrointestinal angiodysplasias
This dissertation focusses on angiodysplasias, vascular malformations in the mucosa of the digestive tract. Karina Grooteman investigated triggers that cause the bleeding, current and new therapeutic options.read more
Karina Grooteman Disease characterization and treatment of gastrointestinal angiodysplasiasAngiodysplasias are vascular malformations in the mucosa of the digestive tract. These abnormal blood vessels tend to bleed easily, especially in older people with kidney or heart diseases. Karina Grooteman investigated triggers that cause the bleeding, current and new therapeutic options. She discovered that patients with angiodysplasias in the stomach and small bowel bleed more frequent than in the colon. Patients with anemia due to the gastrointestinal bleeding had a decreased quality of life. She also found that there is a high variation in treatment strategy between gastroenterologists. There might be room for improvement to treat the abnormal blood vessel during the first endoscopic investigation. For patients with severe bleeding and frequent blood transfusions, octreotide decreases the need of blood transfusions.
Date, time and location PhD defense
- Date: 20 September 2019
- Time: 12:30 hrs
- Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2
Karina Grooteman (1988) studied Medicine at the Utrecht University and obtained her medical degree in 2013. The research in this thesis was performed at the department of Gastroenterology and Hepatology at the Radboud university medical center, within the Radboud Institute for Molecular Life Sciences (RIMLS). Karina started her residency training to become a gastroenterologist in 2017 at the OLVG hospital in Amsterdam.
- Promotor: Prof. J.P.H. Drenth
- Co-promotor: E.J.M. van Geenen, PhD