Jacqueline Ratter The influence of diabetes-associated factors on metabolism and function of human monocytes and macrophages
Diabetes, a state of chronically elevated blood glucose levels, is associated with various long-term complications. Unfortunately, underlying mechanisms remain insufficiently understoodread more
Jacqueline Ratter The influence of diabetes-associated factors on metabolism and function of human monocytes and macrophagesDiabetes, a state of chronically elevated blood glucose levels, is associated with various long-term complications. A disturbed function of innate immune cells is contributing to cardiovascular disease and an increased risk for infections, but underlying mechanisms remain insufficiently understood. Immune cells in patients with diabetes reside in a specific metabolic environment, characterized by altered concentrations of, for example, glucose, lipids and insulin. We found that metabolic changes in patients with diabetes contribute to disturbed immune cell metabolism and function. Better understanding of the effects of the metabolic environment on immune cells in patients with diabetes can help to identify markers for the early detection of diabetic complications and discover targets for future therapies.
Date, time and location PhD defense
- Date: 24 September 2019
- Time: 16:30 hrs
- Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2
Jacqueline Ratter (1990) graduated with cum laude from Radboud University in 2014 (Master's degree in Molecular Mechanisms of Disease). She carried out her doctoral research at the Department of Internal Medicine of the Radboud university medical center. Currently, Jacqueline is working as a postdoctoral fellow at the department of Translational Neuro-oncology at the University hospital in Essen, Germany.
- Promotor(s): prof. C.J.J. Tack PhD and prof. M.G. Netea PhD
- Co-promotor(s): R. Stienstra PhD