SPARXS: Single-molecule Parallel Analysis for Rapid eXploration of Sequence space

Chirlmin Joo TU Delft

Single-molecule fluorescence studies reveal valuable structural and functional information on biomolecules. However, conventional singlemolecule methods have limited sequence diversity due to time, effort and cost constraints. To overcome this, we combine surface-based single-molecule fluorescence with next generation sequencing, enabling massively parallel single-molecule experiments for millions of sequences. Our technique provides sequence-dependent biophysical and biochemical properties at the single molecule level, advancing our understanding of molecular structures and functions and enabling more accurate models in biomolecular engineering.

For all information regarding this seminar, please download the flyer.

• Location

  Figdor Lecture Theatre Research tower 8th floor Route 289 M850.08.024

• Host

  Pascal Miesen

  Medical Microbiology