AboutThis is the 6th ZOO meeting since 1993. The ZOO meeting series has become a landmark event in the field of cell adhesion and migration due to unique theme selection, high scientific profile with excellent speakers and limited number of attendees ( < 200).
The themes address molecular cell biological principles in the fields of cancer and immunology, with focus on cell-tissue interaction, migration and cell-cell communication. The speakers are leaders in their field and all make extensive use of imaging in their research. Scientific sessions will offer the latest developments in mechanobiology, leukocyte trafficking and cancer cell invasion. Live cell confocal imaging, super resolution imaging, quantitative imaging using innovative approaches and biosensors and computational modelling will be highlighted as part of the presentations.
The meeting will be organized in the Rotterdam Zoo conference facilities.
Photo: Wilbert Boelens.
Anna Akhmanova Utrecht UniversityAnna Akhmanova's group studies cytoskeletal organization and trafficking processes, which contribute to cell polarization, differentiation, vertebrate development and human disease. They are interested in understanding, at a systems level, how different aspects of cell architecture are coordinated.
Anna Akhmanova is a recipient of the ALW Vernieuwingsimpuls VIDI in 2001 and VICI awards in 2007, an ERC Synergy grant in 2013, and Spinoza Prize in 2018.
Jason Cyster University of CaliforniaThe major goals of the Cysterlab are (i) Decipher the guidance cue codes controlling leukocyte migration and interaction events during tissue surveillance and immune responses; (ii) Visualize immune response dynamics using advanced imaging approaches; (iii) Define the selection mechanisms for antibody affinity maturation and that help prevent autoantibody production.
Jason Cyster is currently the recipient of an HHMI Investigator Award and 2 NIH grants.
- Ansel KM, Ngo VN, Hyman PL, Luther SA, Forster R, Sedgwick JD, Browning JL, Lipp M, Cyster JG. 2000. A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature 406:309- 314.
- Matloubian M, Lo CG, Cinamon G, Lesneski MJ, Xu Y, Brinkmann V, Allende ML, Proia RL, Cyster JG. 2004. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427:355-360.
- Schwab SR, Pereira JP, Matloubian M, Xu Y, Huang Y, Cyster JG. 2005. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science 309:1735- 1739.
- Allen CD, Okada T, Tang HL, Cyster JG. 2007. Imaging of Germinal Center Selection Events During Affinity Maturation. Science 315:528-531
- Pereira, J.P., Kelly, L.M., Xu, Y. and Cyster, J.G. 2009. EBI2 mediates B cell segregation between the outer and center follicle. Nature 460
- Arnon TI, Xu Y, Lo C, Pham T, An J, Coughlin S, Dorn GW, Cyster JG. 2011. GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood. Science 333:1898-1903.
- Muppidi JR, Schmitz R, Green JA, Xiao W, Larsen AB, Braun SE, An J, Xu Y, Rosenwald A, Ott G, Gascoyne RD, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Vaidehi N, Staudt LM, Cyster JG. Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma. Nature 2014; 516:254-258
Reinhold Förster Hannover Medical SchoolThe working group headed by Prof. Förster sees to the clarification of the cellular and molecular mechanisms forming the basis of the functional organisation of the lymphoid organs. We are particularly interested in clearing up the function of chemokines and chemokine receptors during the migration of immune cells into the secondary lymphoid organs and within these organs.
Reinhold Förster received many grants among SFB grants, DFG grant and an ERC advanced grant in 2013.
Jacco van Rheenen Netherlands Cancer InstituteBy intravital microscopy, the van Rheenen group studies the identity, behavior, and fate of cells that drive tumor initiation, progression, metastasis and the development of therapy resistance.
For his work Jacco van Rheenen received several international awards including the Stem Cells Young Investigator Award, ERC consolidator grant, and the Dr. Josef Steiner Cancer Research Foundation Award.
- Scheele CL, Hannezo E, Zomer A, Langedijk NSM, Simons BD, van Rheenen J, (2017) Identification of mammary stem cells and their dynamics during branching morphogenesis, Nature, 542(7641):313-317.
- Hannezo E, Scheele CLGJ, Moad M, Drogo N, Heer R, Sampogna RV, van Rheenen J#, Simons BD# (2017) A Unifying Theory of Branching Morphogenesis, Cell, Sep 21;171(1):242-255.e27. #co-senior
- Zomer A, Maynard C, Verweij FJ, Kamermans A, Schäfer R, Beerling E, Schiffelers RM, de Wit E, Berenguer J, Ellenbroek SIJ, Wurdinger T, Pegtel DM, van Rheenen J, (2015) In vivo imaging reveals extracellular vesicle-mediated phenocopying of metastatic behavior, Cell, 161(5):1046-1057.
- Ritsma L, Ellenbroek SIJ, Zomer A, Snippert HJ, de Sauvage FJ, Simons BD, Clevers H, van Rheenen J, (2014) Intestinal crypt homeostasis revealed at single stem cell level by in vivo live-imaging, Nature, 507(7492):362-365.
- Xavier Trepat
- Stefan Linder
- Koen van den Dries
- Danijela Matic Vignjevic
- Ben Fabry
- Carsten Grashoff
- Tim Lämmermann
- Philippe Bousso
- Matthew Krummel
- Matthieu Piel
- Andy Ewald
- Kairbaan Hodivala-Dilke
- Michael Dustin
- Fanny Jaulin
- Martin Schwartz
- Stephan Huveneers
- Louis Hodgson
- Paul Kubes
- Sussan Nourshargh
- Anna Huttenlocher
- Steven Pals
Linda Le Noble