Arjan van LaarhovenTuberculosis has plagued humankind since prehistoric times. Over the last century, higher standards of living and the development of antibiotics have significantly reduced the disease burden but still, each year, 1.7 million people die because of tuberculosis globally. This thesis examines the role of the human immune system in tuberculosis. The first part assesses tuberculosis susceptibility and transmission by studying the interaction between white blood cells and various tuberculosis strains. The second part focuses on the high mortality rates associated with tuberculous meningitis by studying cells, proteins and metabolites in blood and cerebrospinal fluid of infected patients. The research in this thesis aims to advance a customized and more effective treatment for this ancient, but still highly relevant disease.
Date, time and location PhD defense Arjan van Laarhoven
- Date: 25 May 2018
- Time: 10:30 hrs
- Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2
Arjan van Laarhoven (1984) graduated from Utrecht University in 2010 (Medicine) and has since alternated between clinical training in Internal medicine (St Antoniusziekenhuis / Rijnstate ziekenhuis / Radboud umc) with research. Based in the lab of Experimental Internal Medicine in Nijmegen, under supervision of Prof. Reinout van Crevel and Prof. Mihai Netea, he worked on tuberculosis projects that resulted in this thesis. Arjan worked at Groningen University and the Broad Institute in Boston, but also spent near to a year in the TB-HIV working group led of Universitas Padjadjaran in Bandung, Indonesia. Here he helped setting up immunological assays to make it possible to perform sophisticated measurements with samples freshly collected from the patients.
- Promotor(s): Prof. R. van Crevel and Prof. M.G. Netea