Christiaan Mooij Cardiovascular risk and steroid precursors in patients with congenital adrenal hyperplasia
Both pediatric and adult patients with congenital adrenal hyperplasia (CAH) have an increased cardiovascular risk. The studies within this thesis show that unfavorable changes in the cardiovascular risk profile of CAH patients can already be seen during childhood.read more
Christiaan Mooij Cardiovascular risk and steroid precursors in patients with congenital adrenal hyperplasiaBoth pediatric and adult patients with congenital adrenal hyperplasia (CAH) have an increased cardiovascular risk. The studies within this thesis show that unfavorable changes in the cardiovascular risk profile of CAH patients can already be seen during childhood. An increased body mass index (BMI), increased body fat percentage, increase blood pressure and insulin resistance may be caused by both the medical treatment as by increased levels of steroid (precursors). Especially an increased BMI seems to play a crucial role in the development of an unfavorable risk profile. Regular evaluation of blood pressure en body weight from a young age will lead to earlier detection of these unfavorable changes.
CAH patients have elevated concentrations of steroid precursors in their blood. Some of these steroid precursosrs seem to have the same potential as cortisol, which is produced insufficiently in CAH. This finding may implicate that patients with sufficient glucocorticoid activity may not require glucocorticoid replacement therapy any longer.
Date, time and location PhD defense
- Date: 12 October 2018
- Time: 12:30 hrs
- Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2
Christiaan Mooij (1986) studied Medicine at the Radboud University Nijmegen and obtained his medical degree in 2008. The research in this thesis was performed at the departments of Pediatric Endocrinology and Endocrinology of Radboud University Medical Center; and at the Centre for Endocrinology, Diabetes and Metabolism of University of Birmingham, United Kingdom. He combined his doctoral research with a residency in pediatrics at the Amalia Children’s Hospital, Radboud University Medical Center. Currently, he is a clinical fellow in pediatric endocrinology at Emma Childrens’s Hospital, Amsterdam university medical centers.
- Promotor(s): Prof. C. Noordam and prof. A.R.M.M. Hermus
- Co-promotor(s): Prof. L. Kapusta and H.L. Claahsen-Van der Grinten, PhD