Dorien Kiers Oxygen and Platelets - Translational studies on therapeutic targets for immunomodulationCritically ill patients at the ICU with either an infection or other diseases regularly have an dysregulated immune response. This research was aimed at modulating these immune responses with exposure to hypoxia and hyperoxia, and antiplatelet therapy. An immune response was evoked in healthy volunteers by administration of bacteria particles. Hypoxia during this immune response reduced the inflammation. Hyperoxia did not affect the immune response. The use of aspirin a week before the administration of bacteria particles resulted in a boosted immune response, and could also partly prevent a paralysed immune response. These interventions are affordable and may in the future amend the dysregulated immune response in critically ill.
Date, time and location PhD defense
- Date: 4 February 2019
- Time: 14:30 hrs
- Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2
Dorien Kiers (1986) obtained her medical degree with honour at the Radboud University in 2011. She performed this research at the Department of Intensive Care Medicine and Anesthesiology at the Radboud university medical center, within the Radboud Institute for Health Sciences. She alternated her research with a residency in internal medicine. She currently is in training to become an internist-intensivist in the Radboudumc .
- Promotor(s): Prof. P. Pickkers and Prof. G.J. Scheffer
- Co-promotor(s): M. Kox, PhD