Floor Aleva Inflammation, coagulation and their interaction in Chronic Obstructive Pulmonary Disease
In this doctoral thesis, the interaction between inflammation and coagulation in COPD patients was investigated.read more
Floor Aleva Inflammation, coagulation and their interaction in Chronic Obstructive Pulmonary DiseaseIn this doctoral thesis, the interaction between inflammation and coagulation in COPD patients was investigated. COPD patients are at increased risk for the development of cardiovascular events, particularly during episodes with increased inflammation, such as acute exacerbations of COPD. To date, the underlying mechanisms are not well defined. Several studies were performed that investigated the interaction between host immune cells and cells involved in coagulation. We found increased interaction between platelets and monocytes in COPD patients and this may play a role in the development of cardiovascular diseases in COPD. Moreover, a study that investigated the association between smoking and immune cell populations in healthy human subjects showed extensive changes in immune cell populations in healthy smokers compared to non-smokers. These data are interesting, as they can shed a light on the mechanisms by which COPD and other smoking-related diseases develop. Knowledge on these mechanisms may help us to prevent the development of cardiovascular diseases in COPD patients in the future.
Date, time and location PhD defense
- Date: 16 February 2018
- Time: 16.30 hrs
- Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2
Floor Aleva (1988) studied Medicine at Radboud University Nijmegen and obtained her degree in 2014. The research in this thesis was performed at the departments of Respiratory diseases and Internal Medicine of the Radboud University Medical Center. Floor currently started a residency program in Respiratory Diseases.
- Promotor: Prof. dr. A.J.A.M. van der Ven, Prof. dr. Y.F. Heijdra
- Co-promotor: dr. Q. de Mast