Hanne Rooijackers Impaired awareness of hypoglycemia in type 1 diabetes. The role of lactate
Approximately one out of three patients with type 1 diabetes has a reduced ability to detect symptoms of hypoglycemia.read more
Hanne Rooijackers Impaired awareness of hypoglycemia in type 1 diabetes. The role of lactateApproximately one out of three patients with type 1 diabetes has a reduced ability to detect symptoms of hypoglycemia. This condition is referred to as impaired awareness of hypoglycemia and is dangerous because it increases the risk for severe hypoglycemia up to sixfold. The precise mechanisms underlying IAH remain unknown, but adaptations in the brain’s handling of energy substrates are likely involved. Rooijackers aimed to investigate the role of lactate in the development of IAH. Under resting conditions, glucose is the main fuel for the brain, but the brain is able to use other, alternative fuels, such as lactate. In a series of studies Rooijackers and colleagues measured brain lactate concentrations in several groups of patients under different circumstances (i.e., during hypoglycemia and during normal blood glucose levels, and when blood lactate levels were in the normal range, or elevated). Rooijackers discovered several adaptations in brain lactate handling in patients with IAH. These adaptations are likely aimed at protecting the brain, by preserving brain metabolism during hypoglycemia. At the same time, these adaptations may impede hypoglycemia sensing by the brain and contribute to the development of IAH.
Date, time and location PhD defense
- Date: 22 November 2018
- Time: 10:30 hrs
- Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2
Hanne Rooijackers (1988) studied Medine at the Radboud University Nijmegen and obtained her medical degree (cum laude) in 2014. She worked from 2014 to 2017 at the Radboud university medical center and investigated the pathogenesis of impaired awareness of hypoglycemia. This research was a close collaboration between the department of Radiology and Nuclear medicine, and the departement of Internal Medicine. In 2018 Hanne Rooijackers started her residency in Internal Medicine at the Canisius Wilhelmina Hospital in Nijmegen.
- Promotor(s): Prof. C.J.J. Tack and Prof. A. Heerschap
- Co-promotor(s): B.E. de Galan, PhD and M. van der Graaf, PhD