Ilse Dingjan Radical view on antigen cross-presentation in dendritic cells
A small subset of immune cells, including dendritic cells, can take up pathogens or malignant cells.read more
Ilse Dingjan Radical view on antigen cross-presentation in dendritic cellsA small subset of immune cells, including dendritic cells, can take up pathogens or malignant cells. These cells then present these invaders to other immune cells in a process called antigen cross-presentation. Cross-presentation is required for inducing a proper immune response against the invaders. An important protein complex involved in antigen cross-presentation is the NADPH oxidase NOX2. However, the mechanism of NOX2 action was not known. Within dendritic cells, NOX2 is present on the membrane of vesicles containing the invader, called phagosome, where it produces free oxygen radicals. We demonstrated that these radicals can induce leakage of the phagosome, which is necessary for antigen cross-presentation. However, these radicals can also oxidize NOX2 itself, leading to breakdown of oxidized NOX2 by a novel cellular mechanism. The obtained results have led to a more complete understanding of the role of NOX2 and antigen degradation mechanisms in antigen cross-presentation. Furthermore, the findings have set a basis for new insights in the way radicals activate and regulate the immune system.
Date, time and location PhD defense
- Date: 29 March 2018
- Time: 12:30 hrs
- Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2
Ilse Dingjan (1989) studied Oncology at the VU University in Amsterdam and obtained her master degree in 2013. The research in this thesis was performed at the department of Tumor Immunology of the Radboud University Medical Center, within the Radboud Institute for Molecular Life Sciences. She currenlty works as a postdoctoral fellow at the deparment of Tumor Immunology of the Radboud University Medical Center, where she continued this project.
- Promotor(s): prof. C.G. Figdor
- Co-promotor(s): dr. G. van den Bogaart