Jinlong Shao The incorporation of silver to enhance the antibacterial properties of biomaterialsThis thesis explored the use of silver to enhance the antibacterial efficacy of polymeric biomaterials. The silver loaded polymers displayed a sustained release of silver ions and correspondingly exhibited prolonged antibacterial properties against anaerobic gram-positive and gram-negative bacteria (Chapter 3) as well as aerobic gram-positive and gram-negative bacteria (Chapter 4, 5, and 6). The silver loaded chitosan-based membranes did not evoke a stronger subcutaneous inflammatory response on compared to the membranes without silver (Chapter 3) and did not alter the cutaneous wound healing ability of skin wounds (Chapter 6). Nonetheless, since the design of medical devices is determined by their application site, the antibacterial efficacy of biomaterials must be assessed for a specific application as well as situation in which the biomaterials are used. Therefore, this thesis is an initial step towards the translation of the incorporation of the silver to enhance the antibacterial effect of biomaterials for biomedical applications. More researches have to be done to determine the final benefit of silver-based biomaterials and their human clinical application.
Date, time and location PhD defense
- Date: 10 December 2018
- Time: 12:30 hrs
- Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2
Jinlong Shao (1989) graduated with first-class honors in 2014 from Shandong University (Master's degree in Dentistry). He carried out the above doctoral research at the Department of Biomaterials of the Radboud University Nijmegen Medical Center, within the Radboud Institute of Molecular Life Sciences (RIMLS). His project is focused on the incorporation of silver to enhance the antibacterial properties of biomaterials.
- Promotor(s): prof. J.A. Jansen
- Co-promotor(s): F. Yang, PhD X.F. Walboomers, PhD