Julia Odenthal Cancer invasion - Growth factor-induced mechanisms and targeting by image-guided surgeryTo improve head and neck squamous cell carcinoma (HNSCC) treatment, it is important to understand the basis of HNSCC tumor cell invasion and to optimize surgical outcomes.
The first part of the thesis describes current concepts and functional consequences of growth factor and cytokine signaling in cell invasion programs. Furthermore, growth factors are identified to induce the transcriptional program EMT together with various migration strategies. This indicates EMT as a probabilistic molecular program, in association with any invasion strategy.
As most promising strategy to improve surgical outcomes, fluorescence-guided surgery (FGS) aiming to identify the tumor margin shows great potential to guide and improve the precision of surgical excision. In the second part of the thesis we demonstrate the suitability for FGS in a preclinical model of invasive HNSCC by using the monoclonal anti-CD44v6 antibody BIWA. Furthermore, we demonstrate that the irradiation by a CO2 laser does not interfere significantly with the fluorescence signal.
Finally, the relevance of cell invasion strategies for local tumor cell dissemination, the challenges of tumor cell migration strategies on cancer treatment and the perspectives for targeting cancer invasion by surgical and molecular therapy are discussed.
Date, time and location PhD defense
- Date: 10 December 2018
- Time: 16:30 hrs
- Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2
Julia Odenthal (1986) studied Molecular Biology and Biomedical Sciences at the Bonn-Rhein-Sieg University of Applied Sciences, the University of Aberdeen and the Radboud University Nijmegen. After obtaining her master’s degree in 2011 she started her PhD studies at the Department of Otorhinolaryngology and Head and Neck Surgery (Radboudumc) in collaboration with the Department of Cell Biology (RIMLS). Currently, she works as healthcare consultant at hict, in Bruges, Belgium.
- Promotor(s): Prof. P.H.A. Friedl
- Co-promotor(s): R.P. Takes, PhD