Peter Uijtdewilligen Towards embryonic scaffolds for regenerative medicine - Glycosaminoglycans, effector molecules and collagen
Based on the observation that skin heals without a scar during embryonic development, we investigated the possibilities of using principles found in embryonic development to design novel constructs.read more
Peter Uijtdewilligen Towards embryonic scaffolds for regenerative medicine - Glycosaminoglycans, effector molecules and collagenBased on the observation that skin heals without a scar during embryonic development, we investigated the possibilities of using principles found in embryonic development to design novel constructs. Such constructs may induce embryonic-like processes, potentially, and result in scarless healing when used for the treatment of full-thickness skin wounds. A comparison between two time points during embryonic development (E14 and E16), and one postnatal time point (P1) against adult skin (P90), resulted in a list of 20 growth factors. Two growth factors were selected and were successfully incorporated into a type I collagen-heparin scaffold. In addition, we created type I collagen scaffolds containing hyaluronic acid, since hyaluronic acid is suggested to be important during embryonic wound healing. During embryonic development gradients of effector molecules are important. In the thesis we present briefly the development of a scaffold containing a gradient of heparin. Overall we have set the first steps in the construction of embryonic scaffolds for tissue engineering, focusing on glycosaminoglycans, effector molecules and collagen.
Date, time and location PhD defense
- Date: 19 February 2018
- Time: 10.30 hrs
- Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2
Peter Uijtdewilligen was born August 5th, 1980 in Utrecht, The Netherlands. He studied Biotechnology at the Wageningen University. After finishing his study in 2005 he started his Ph.D. research project at the Department of Biochemistry part of the Radboud Institute for Molecular Life Sciences of the Radboud university medical centre. The research presented was part of the Dutch Program for Tissue Engineering, which focused on various applications of tissue engineering. This thesis is part of the subproject, which focused on skin tissue engineering. Peter is now working as a chemistry teacher at CSG Het Streek in Ede, The Netherlands. He obtained his teaching license in 2013 at the University of Utrecht. In addition to teaching chemistry he teaches a project-based course called “Technasium” in which students are involved in a technical-oriented assignment from local companies.
- Promotor: Prof. dr. R.E. Brock
- Co-promotor: Dr. A.H.M.S.M. van Kuppevelt, Dr. ir. W.F. Daamen