Agenda PhD defense Ralph Slijkerman

Ralph Slijkerman Splice modulation as potential therapy for Usher syndrome IIa

Usher syndrome is a rare hereditary disease that manifests itself through congenital hearing loss and progressive loss of vision from around puberty onwards.

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Ralph Slijkerman Splice modulation as potential therapy for Usher syndrome IIa

Usher syndrome is a rare hereditary disease that manifests itself through congenital hearing loss and progressive loss of vision from around puberty onwards. The most common cause of this disease is one of several mutations in the USH2A gene. Currently, patients can be aided with cochlear implants, but no treatment for the loss of vision is present. Ralph Slijkerman's research has taken a number of important steps towards the development of such a treatment. He has used gene editing techniques to generate zebrafish animal models and at the same time designed antisense oligonucleotides to influence RNA splicing of USH2A transcripts. Subsequently, he demonstrated that these antisense oligonucleotides in the zebrafish are capable of prevent USH2A-associated retinal degeneration.
 

Date, time and location PhD defense

  • Date: 17 January 2019
  • Time: 12:30 hrs
  • Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2

Biography

Ralph Slijkerman (1990) studied Molecular Life Sciences at the Radboud University and obtained his master degree bene meritum in 2013.

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Biography

Ralph Slijkerman (1990) studied Molecular Life Sciences at the Radboud University and obtained his master degree bene meritum in 2013. The research in this thesis was performed at the department of otorhinolaryngology in the Radboud university medical center. Currently, Ralph is employed as Science and Business Fellow at Janssen Vaccines & Prevention B.V. in Leiden, part of the Johnson and Johnson Family of Companies.
 


Promotor

  • Promotor(s): Prof. J.M.J. Kremer
  • Co-promotor(s): H.A.R. van Wijk, PhD and R.J.E. Pennings, PhD

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