Rebecca Rogier The role of intestinal microbiota in T cell-mediated experimental arthritis. Lessons from the mouse gut
Our results suggest that the modulation of the intestinal microbiome or suppression of Th17-inducing bacteria may offer novel therapeutic strategies for rheumatoid arthritis.read more
Rebecca Rogier The role of intestinal microbiota in T cell-mediated experimental arthritis. Lessons from the mouse gutWe show that there is a shift in the composition of the intestinal microbiome in arthritic mice. In addition, we show that this shift already take place in the preclinical phase of arthritis, before any sings of joint inflammation are detectable. The change in the microbiome was accompanied with activation of the intestinal immune system. Moreover, we show that treating mice with an antibiotic cocktail results in a strong suppression of arthritis. Interestingly, we observed a strong correlation between the amount of Th17 cells in the intestine and arthritis severity. This supports the idea that there is a link between intestinal microbiome-induced Th17 cells and autoimmune arthritis. Our results suggest that the modulation of the intestinal microbiome or suppression of Th17-inducing bacteria may offer novel therapeutic strategies for rheumatoid arthritis.
Date, time and location PhD defense
- Date: 19 February 2019
- Time: 14:30 hrs
- Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2
BiographyRebecca Rogier (1988) studied Medical Biology at the Radboud University and obtained her master’s degree in 2013. The research in this thesis was performed at the department of experimental Rheumatology of the Radboud university medical center, within the Radboud Institute for Molecular Life Sciences. Currently she is a Quality Assurance Office at Eurotrol in Ede, the Netherlands.
- Promotor(s): Prof. P.M. van der Kraan and Prof. W.B. van den Berg
- Co-promotor(s): S. Abdollahi-Roodsaz, PhD and M.I. Koenders, PhD