Sanne van Raaij Coming into view: Renal iron handling in human health and disease
With the research that is presented in this thesis, Sanne van Raaij has increased the knowledge on the proteins that transport iron in the kidney.read more
Sanne van Raaij Coming into view: Renal iron handling in human health and diseaseThe metal iron (Fe) is essential for a large number of processes in the human body. However, it can also be deleterious by catalyzing the formation of reactive oxygen radicals. Over the past few years, there is increasing evidence that iron can be involved in causing renal injury. With the research that is presented in this thesis, Sanne van Raaij has increased the knowledge on the proteins that transport iron in the kidney. Moreover, she showed that chronic iron exposure can cause injury to the kidneys in patients with systemic iron overload. Also in patients with kidney diseases, she found that iron deposition may play a role in causing renal injury: Iron was detected in the kidney tubules of as much as 33% of the studied patients with renal diseases. These new findings may potentially contribute to finding new therapies that can aid in decreasing iron-mediated injury in the kidney.
Date, time and location PhD defense
- Date: 19 February 2019
- Time: 16:30 hrs
- Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2
BiographySanne van Raaij (1990) graduated in 2013 with honors from the Radboud University (Master’s in Biomedical Sciences). She carried out the above doctoral research at the department of Laboratory Medicine (within the Translational Metabolic Laboratory) of the Radboud university medical center, within the Radboud Institute for Molecular Life Sciences. Currently, she is a Country Approval Associate at PPD and facilitates clinical research.
- Promotor(s): Prof. D.W. Swinkels and Prof. R. Masereeuw (UU)
- Co-promotor(s): R.P.L. van Swelm, PhD