Simone Mastrogiacomo Pre-clinical Imaging Strategies for Bone and Dental Restorative Biomaterials
Every year, more than two million patients worldwide undergo bone transplantation for several reasons, like traumatic injuries.read more
Simone Mastrogiacomo Pre-clinical Imaging Strategies for Bone and Dental Restorative BiomaterialsEvery year, more than two million patients worldwide undergo bone transplantation for several reasons, like traumatic injuries. To date, many compatible materials, such as ceramics, have been used in dental and orthopedic practice in order to facilitate tissue repair and healing. However, because of the high similarity between the currently used restorative materials and the natural bone and dental tissues, their visualization in vivo is challenging, especially by using conventional X-ray technologies. For this reason within my Ph.D. thesis, I investigated new imaging strategies that can be used to follow bone and dental dedicated materials once implanted into the body. Through the combination of well-defined compatible materials with magnetic resonance imaging (MRI) and computed tomography (CT) dedicated contrast agents I developed innovative compositions that can be easily monitored over the time and in a non-invasive fashion. I tested and proved the visibility and compatibility of the new developed compositions in animal models (e.g. rat and goat). Therefore, within this thesis, I provided a wide platform of MRI and CT visible materials that can be used for bone and dental applications.
Date, time and location PhD defense
- Date: 19 April 2018
- Time: 14:30 hrs
- Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2
Simone Mastrogiacomo (1985) received the Master’s degree in 2012 in Medical, Veterinary and Pharmaceutical Biotechnologies at the University of Parma, Italy. In 2013, Mastrogiacomo started the above doctoral research at the Department of Biomaterials of the Radboud University Nijmegen Medical Center. His Ph.D. project was part of Marie Curie Initial Training Network (iTERM) founded by the European Union. During his Ph.D. studies, he was a visiting researcher at the Department of Chemistry, Hull University, United Kingdom, and at the Nano4Imaging GmbH, Aachen, Germany.
- Promotor(s): Prof. John Jansen
- Co-promotor(s): Dr. Frank Walboomers