Will Stone Malaria: what affects who infects?Malaria is conventionally controlled using drugs to kill the parasite that causes the disease, and insecticidal nets to prevent the parasites transmission to and from mosquitoes. Unfortunatley, the malaria parasite is becoming resistant to our latest drugs, and mosquitoes resistant to our newest insecticides. Eliminating malaria requires new approaches that can stop the parasite in its tracks. New drugs and vaccines which specifically aim to stop people being infectious to msoquitoes may be the key to achieving elimination. In this thesis, we dissect the factors that determine wether people pass on malaria parasites to mosquitoes when they get bitten. We assess the various ways we can measure human infectiousness, with a view to measuring this during surveillance, and facilitating the development of transmission-blocking drugs and vaccines. Finally, we dive deeper into the immune mechanisms that stop some people infecting mosquitoes, uncovering antibody responses that could be exploited as vaccine candidates.
Date, time and location PhD defense
- Date: 22 February 2018
- Time: 16.30 hrs
- Location: Radboud Universiteit, Academiezaal Aula, Comeniuslaan 2
Will Stone (1988) graduated from the London School of Hygiene and Tropical Medicine (LSHTM) with distinction in 2011. He worked for LSHTM in Kenya for 4 months, then moved to the Nijmegen, the Netherlands, to begin his PhD in Robert Sauerwein and Teun Bousema’s group at the Medical Microbiology department of Radboud UMC. He has continued to work with Radboud UMC and with LSHTM, and is now based in London where he will begin his post-doctoral research into malaria transmission biology.
- Promotor: Prof. R.W. Sauerwein Prof. C.J. Drakeley
- Co-promotor: Dr. T. Bousema