Importance of prospective studies in pregnant and breastfeeding women living with HIV14 March 2019
In Clinical Infectious Diseases Angela Colbers, Stein Schalkwijk and David Burger give considerations on how to effectively evaluate aspects of clinical pharmacology required for safe and effective treatment to optimize pharmacotherapy during pregnancy and breastfeeding.
Effect of prolonged antibiotic treatment on cognition in patients with Lyme borreliosis5 March 2019
In Neurology Anneleen Berende, Roy Kessels, Bart-Jan Kullberg and colleagues showed that longer-term antibiotic treatment did not lead to better cognitive performance compared to a 2-week regimen in patients with Lyme disease-attributed persistent symptoms.
15 million Euro to identify new drug targets for HIV28 February 2019
André van der Ven and Mihai Netea, theme Infectious diseases and global health, and colleagues, will receive 15 million Euro from pharmaceutical company ViiV Healthcare for research into new ways to fight the HIV virus. The aim of the HIV 2000+ project is to identify new drug targets for HIV.
ZonMw TOP grant to uncover the dormancy of malaria parasites7 February 2019
Richard Bartfai, theme Infectious diseases and global health, and Clemens Kocken (BPRC) received 675,000 euros from ZonMw to uncover the molecular mechanisms underlying dormancy of malaria parasites, a major obstacle to efficient treatment of P. vivax malaria.
KNAW Ammodo Award for Teun Bousema1 February 2019
Each of the laureates of this prestigious award for top researchers in the Netherlands receive a monetary prize of 300,000 euro. The funds can be used to explore new directions in pure scientific research. Bousema is one of the eight laureates of 2019.
A personal touch of Febrina Meutiawati20 January 2019
In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t! This week: Febrina Meutiawati.
LEO Foundation grant for Ellen van den Bogaard and Patrick Zeeuwen17 January 2019
LEO Foundation ‘Open competition grants’ are given to support the best dermatology research projects worldwide that improve the understanding of the underlying medicinal, biological, chemical, or pharmacological mechanisms of dermatological diseases and their symptoms.
A personal touch of Dimitri Diavatopoulos13 December 2018
In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t! This week: Dimitri Diavatopoulos.
Five RIMLS researchers in top 1 percent by citations13 December 2018
Bas Dutilh, Leo Joosten, Jos van der Meer, Mihai Netea and Henk Stunnenberg made it to this year’s list of highly cited researchers. Researchers in this list are selected for their exceptional research performance and are regarded to have had a major impact on fellow scientists.
Sepsis-associated acute kidney injury: A randomized clinical trial15 November 2018
Peter Pickkers, theme Infectious diseases and global health, published in JAMA, that among patients who were critically ill with sepsis-associated acute kidney injury, human recombinant alkaline phosphatase compared with placebo did not significantly improve short-term kidney function.
Report of the 12th New Frontiers symposium Big data, better healthcare? - 1 November 20187 November 2018
Examples from the application of deep learning to image reading in pathology and radiology and the application of network medicine to monitor infectious disease outbreaks or collective mood states using twitter data showed the huge potential of big data approaches for building better healthcare.
Report of the 12th New Frontiers symposium Better care, network care? - 2 November 20187 November 2018
No easy answers at this symposium last Friday, only challenges that can be overcome if we succeed in 5 things. First and most radically, put patients in the center of healthcare. Second, start with assessing what the local population needs and not what local professionals have to offer.
The itaconate pathway as a central regulatory node linking innate immune tolerance and trained immunity26 October 2018
Jorge Domínguez-Andrés and Mihai Netea demonstrate in Cell Metabolism, the importance of the IRG1-itaconate-SDH axis in the development of immune tolerance and trained immunity, and highlight the potential of β-glucan as a tool to revert immune paralysis induced by sepsis.
Pharmacy receives prestigious European prize for research in Africa27 September 2018
On 17 September, David Burger, professor of clinical pharmacy, together with colleagues from the United Kingdom, Uganda and Zimbabwe, received the "Outstanding Research Team" award from the European - Developing Countries Clinical Trial Partnership (EDCTP).
Brain specific mutations may only explain sporadic Alzheimer's disease in very few cases20 August 2018
Alexander Hoischen, theme Infectious diseases and global health, and colleagues studied brain- and blood-DNA of sporadic early-onset Alzheimer’s disease (AD) patients, for somatic mutations in the known AD genes.
WHO Toolkit Pregnant and breastfeeding women8 August 2018
Stein Schalkwijk, Angela Colbers and David Burger (Pharmacy) developed the Toolkit in cooperation with Mark Mirochnick (Boston University) as a part of “Toolkit for research and development of paediatric antiretroviral drugs and formulations”.
Veterinary drug can prevent outbreaks of malaria and Zika in humans5 July 2018
Drugs that protect pets against ticks and fleas can also be used to prevent outbreaks of malaria, Zika and dengue fever in humans. This was the conclusion of an article by scientists from TropIQ Health Sciences, together with English and American colleagues, and published in the journal PNAS.
Pneumococcal DNA predicts course of infection4 July 2018
In Clinical Infectious Diseases, Radboudumc researchers describe several pneumococcal genes predicting whether a patient runs the risk of developing meningitis or dying from the disease. Use of such genetic tests can improve infection diagnostics.
Pharmacokinetics of HIV medicines in pregnant women28 June 2018
In Clinical Pharmacokinetics David Burger, Ruben van der Galiën and colleagues discuss that although yearly over a million of women with HIV get pregnant, it is often still unknown whether treatment with HIV-integrase inhibitors results in adequate drug exposure.