Controlled Human infection models (CHIM) aim to better understand the interaction between an infectious agent and the human host. In this clinical model, a well-characterised infectious agent or micro-organism, is given to carefully selected healthy adult volunteers followed by stringent clinical follow-up and final treatment. Safety of the participating volunteers is a leading principle. These studies play a vital role in helping to accelerate clinical development of new vaccines and drugs for specific infectious diseases. Radboudumc Center for Infectious Diseases will initially focus on controlled human infection models for malaria, sepsis and respiratory infections.