Education Events All events 10081 4th International Conference on Innate Immune Memory

About the event

The Radboud university medical center for Infectious Diseases invites you on October 31 and November 1st to the international symposium ‘4th International Conference on Innate Immune Memory’ in the city of Nijmegen, the Netherlands.

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About the event

This international conference will cover novel aspects on innate immune memory, starting from evolutionary aspects, to molecular mechanisms, and translational aspects important for infections, vaccination, inflammatory diseases and cancer. An international group of experts in the field will present their work, including Kenneth Walsh, Michael Skinner, Joachim Schultze, Maria-Carla Saleh, Joseph Sun, Triantafyllos Chavakis, Keiko Ozato, Maziar Divangahi, Mihai Netea, Robin Choudhury, Luis Barreiro, Musa Mhlanga, Ramnik Xavier, Christine Stabell-Benn, Nigel Curtis, Willem Mulder.
In addition, oral presentations will be chosen from the submitted abstracts, and a ‘Best Oral Presentation Prize’ and ‘Best Poster prize’ will be awarded.
We would like to invite colleagues in the field to join us in this very exciting scientific meeting. The deadline for abstract submission is 15 September 2019, and for registration is 15 October 2019. The early bird fee is 300 euros and includes registration, lunches and the congress dinner. There will be a limit of 300 participants for the conference.
Looking forward to welcome you in Nijmegen,
Mihai Netea
Leo Joosten
Triantafyllos Chavakis


4th International Conference on Innate Immune Memory - Abstracts
1. Intergenerational inheritance of trained immunity and heterologous resistance to infections. - Dominguez Andres, Jorge
2. Harnessing innate immune memory induced by vaccine prime : timing and route of administration matter - BEIGNON, Anne-Sophie
3. Superior Induction of trained immunity by mucosal BCG vaccination in nonhuman primates - Vierboom, Michel
4. Single-cell variation in beta-glucan induced trained immunity - Randolph, Haley E.
5. Training of hematopoietic stem cells by helminth products induces long-term anti-inflammatory trained immunity that protects against autoimmune disease - Cunningham, Kyle
6. Transcriptomic response of human monocytes to ovulation and pregnancy hormones - Novakovic, Boris
7. Identification of DNA methylation patterns predisposing for an efficient response to BCG vaccination in healthy BCG-naïve subjects - Das, Jyotirmoy
8. Boosting Trained Immunity By Targeting Ship-1 In Myeloid Cells. - Del Fresno, Carlos
9. Norepinephrine exerts anti-inflammatory effects in mice and humans in vivo, and compromises host defense during experimental sepsis - Stolk, Roeland
10. Anti-inflammatory effects of phenylephrine in mice and humans mediated via the beta adrenergic receptor - Stolk, Roeland
11. Connecting trained innate immunity and adaptive immune responses: nonspecific protection to immunological memory - Helder, Leonie
12. Mitochondrial adaption gives rise to oxidized low density lipoprotein-induced trained immunity via the production of mitochondrial superoxides and mitochondrial networks - Groh, Laszlo
13. Trained immunity confers broad-spectrum protection against bacterial infections - Ciarlo, Eleonora
14. Immunomodulatory effects of itaconate - Ferreira, Anaisa
15. Innate immune memory and tuberculosis: Using live cell imaging for studying Mycobacterium tuberculosis-infected human macrophages. - Braian, Clara
16. Leishmania braziliensis induces metabolic rewiring and epigenetic alterations in human monocytes resulting in trained Immunity - Santos, Jéssica dos
17. C/EBPb dependent Epigenetic Immune Memory in Hematopoietic Stem Cells - Laval, Bérengère de
18. A genome-wide association study identifies KDM4 histone demethylase as an important modulator of trained immunity - Moorlag, Simone
19. Circadian rhythm influences induction of trained immunity by BCG vaccination - Bree, Charlotte de
20. The sublingual polybacterial preparation MV130 reduces children’s wheezing attacks and triggers trained immunity - Conejero, Laura
21. Myeloid cell reprogramming in non-medullary thyroid carcinoma – an explorative study in progress - Grondman, Inge
22. Trained immunity protects from pneumococcal pneumonia - Théroude, Charlotte
23. Trained immunity confers long-term protection against systemic listeriosis - Heinonen, Tytti
24. Trained Innate Immunity in Dogs – Shared Features and Differences Between Human and Mice. - Paris, Simon
25. Potential role for DNA – sensing receptors in pathophysiology of primary Sjögren’s syndrome - Huijser, Erika
26. Histone methyltransferase G9a inhibits ß-glucan induced trained immunity by H3K9 dimethylation - Mourits, Vera
27. Prior IL-4 exposure induces chromatin remodeling and the rearrangement of LPS-activated p65 cistrome, leading to synergistic transcriptional activation of a specific gene set in macrophages - Czimmerer, Zsolt
28. Zbtb46 mediated suppression of the embryonic stem cell derived myeloid lineage development - Boto, Pal
29. Innate immune Training of granulopoiesis promotes anti-tumor activity - Kourtzelis, Ioannis
30. ‘Trained’ macrophages accellerate tissue factor-mediated blood coagulation - McCluskey, Seán
31. Training the innate immune system reverses age related changes to the fecal microbiome - Gill, P. Spencer
32. Innate immune training modulates myeloid derived suppressor cell (MDSC) populations in polymicrobial sepsis - Gill, P. Spencer
33. Sex-specific regulation of inflammation and metabolic syndrome in obesity – a trained phenotype in men - Horst, Rob ter
34. Endotoxin-induced changes in functionality and single-cell gene expression of monocytes and bone marrow progenitors of healthy volunteers - Leijte, Guus
36. Epigenetic Reprogramming in Lung Immune Cells to identify Tuberculosis Exposure - Pehrson, Isabelle
37. A DNA methylome biosignature in immune cells recovered from induced sputum from TB-exposed individuals predicts exposure to mycobacteria across multiple cell types. - Idh, Nina
38. T Cell Characterization in Auto-inflammatory Syndromes - Al, Burcu
39. Role of Trained Immunity in the pathogenesis of Erdheim-Chester Disease - Cavalli, Giulio
40. Cell Therapy with adipose-derived mesenchymal stromal cells induces an early innate immune memory response that protects to secondary acute inflammation in experimental colitis - Lopez-Santalla, Mercedes
41. Cohesin is required for establishment but not maintenance of IFN-gamma induced long-term transcriptional memory of the GBP gene cluster. - Siwek, Wojciech
42. In vitro studies on innate training of porcine monocytes - Jansen, Christine
43. Immunometabolic programs explain variation in BCG-induced trained immunity in healthy volunteers. - Koeken, Valerie A. C. M.
44. Trained immunity modulates inflammation-induced fibrosis - Jeljeli, Mohamed Maxime
45. Immunomodulatory effects of trained immunity in endometriosis in mice and human - Jeljeli, Mohamed Maxime
46. Trained immunity in pneumococcal infection: in vitro experiments - Toullec, Laurie
47. The role of transcription factors in long-term transcriptional memory in human cells. - S.H Tehrani, sahar
48. Heme-induced trained immunity protects against polymicrobial sepsis - Jentho, Elisa
49. TLR agonists mediate protection against severe nosocomial infections via activation of MYD88 - Bohannon, Julia
50. Anti-inflammatory cytokines differentially influence innate immune memory - Röring, Rutger Jan
51. BCG vaccination induces long-term functional reprogramming of human neutrophils - Moorlag, Simone
52. The impact of urbanization on innate immune response in healthy Tanzanian individuals - Temba, Godfrey
53. Single Cell RNA sequencing reveal heterogeneity of cellular response to stimulations of trained immunity - Zhang, Bowen
54. BCG vaccination induces innate immune training in adults over 50 years of age - Berendsen, Mike LT
55. Toll-like receptor 4 agonist-induced mitochondrial biogenesis, Irg1 expression and itaconate production protect against infection with common nosocomial pathogens - Patil, Naeem K.
56. Phosphorylated hexaacyl disaccharides induce trained innate immunity and resistance to infection with common nosocomial pathogens - Hernandez, Antonio
57. Can BCG-mediated protection be vertically transmitted? - Kaufmann, Eva
58. Trained Innate Immunity in Non-Immune Cells: Lessons From Priming Human Coronary Smooth Muscle Cells and Endothelial Cells - Sohrabi, Yahya
59. Regulation of type 1 interferon signaling pathway by uric acid treatment in primary human mononuclear cells - Badii, Medeea Oana
60. Induction of Trained Innate Immunity in Human Monocytes by Aspergillus fumigatus - Bruno, Mariolina
61. Beta-Glucan Protects Mice from Pseudomonas aeruginosa Infection: Insights into the Signaling Mechanisms Underlying Innate Immune Memory - Stothers, Cody
62. The role of Mll3 and Mll4 histone methyltransferases in macrophage function - Alvarez, Yubell
63. Trained autoimmunity as a driver in the pathogenesis of Systemic Lupus Erythematosus - Yanginlar, Cansu
64. The influence of genetic background on trained innate immunity in chicken macrophages. - Verwoolde, Michel B.
65. Mevalonate pathway blockage impairs cytokine production by human gd T cells. - Placek, Katarzyna
66. The single-cell chromatin landscape of human immune responses to inactivated vaccines - Wimmers, Florian
67. A B-cell/Neutrophil axis orchestrates tissue tolerance during sepsis - Gawish, Riem
68. Preoperative determination of the individual immune response of patients with systemic inflammatory response syndrome after cardiac surgery. - Bode, Christian
69. A gammaherpesvirus infection blocks for the long term the functionality of group 2 innate lymphoid cells. - Gillet, Laurent
70. BCG-training enhances adaptive immune responses to subsequent acellular pertussis booster vaccination in humans - Gillard, Josh
71. Development of a trained immunity and resilience model for testing of orally applied ß-glucans or other immunomodulatory compounds - Moerings, Bart
72. Innate immune control of chronic infection in a rodent malaria model - Matthew Lewis
73. Long-term adaptation in fatty acid-primed monocytes - Anna C. Aschenbrenner
74. Early aging of monocytes in MDD. A role of mevalonate kinase (MVK) in enhancing low grade inflammation after childhood adversity (CA) - Maria Susanne Simon
75. Circadian rhythm influences induction of trained immunity by BCG vaccination - L. Charlotte J. de Bree
76. Small molecule screen identifies modulators of macrophage activation and innate immune training - Sinu P. John
77. Immunological memory of Group 2 Innate Lymphoid Cells - Itziar Martinez-Gonzalez


Thursday October 31

8.45 Welcome and Introduction Mihai Netea and Leo Joosten
Innate immune memory – evolutionary aspects (chair: Jos van der Meer)
9.00     Joachim Schultze: Immune memory as an evolutionary continuum
9.30     Joseph Sun: NK cell memory
10.00   Godfrey Temba: Urbanization and innate immune response in Tanzania
10.15   Anna Aschenbrenner: Long-term adaptation in fatty acid-primed monocytes 
10.30   Break
Cellular substrates of innate immune memory (chair: Eicke Latz)
11.00   Keiko Ozato: IFN-induced epigenetic reprogramming
11.30   Stephanie Fanucci: The role of lncRNAs in trained immunity
12.00   Florian Wimmers: Single-cell chromatin landscape after inactivated vaccines
12.15   Cansu Yanginlar: Trained autoimmunity in Systemic Lupus Erythematosus
 12.30 Lunch and posters
Innate immune memory mechanisms (1) (chair: Giuseppe Matarese)
14.00   Triantafyllos Chavakis: Mechanisms of trained immunity induced by beta-glucan
14.30   Maz Divangahi: BCG and reprogramming of bone marrow myeloid progenitors
15.00   Carlos del Fresno: Boosting Trained Immunity by Targeting Ship-1
15.15   Bérengère de Laval: C/EBPb dependent Epigenetic Immune Memory in HSC
15.30   Break
Innate immune memory mechanisms (2) (chair: Zoltan Fehervari)
16.00   Robin Choudhury: Hyperglycaemia-induced trained immunity in macrophages and their precursors promotes atherosclerosis
16.30   Willem Mulder: Nanobiologics and modulation of trained immunity
17.00   Keynote – Kenneth Walsh: Clonal hematopoesis
17.45   Congress dinner (buffet)


Friday November 1st

Epigenetic mediation of innate immune memory (chair: Leo Joosten)
9.00     Luis Barreiro: Deciphering trained immunity through single-cell technologies
9.30     Ramnik Xavier: Single-cell transcriptomics in BCG vaccination
10.00   Michel Vierboom: Trained immunity by mucosal BCG vaccination in NHP
10.15   Spencer Gill: Trained immunity reverses age related fecal microbiome
10.30   Break
Trained immunity in disease: pathophysiology (chair: Niels Riksen)
11.00   Eicke Latz: Trained immunity in atherosclerosis
11.30   Shabaana Khader: Macrophage reprogramming in TB
12.00   Laura Conejero: MV130 reduces wheezing and triggers trained immunity
12.15   Kyle Cunningham: Helminth products induce trained immunity
 12.30   Lunch and posters
Trained immunity in disease: prophylaxis and treatment (chair: Reinout van Crevel)
14.00   Elisa Jentho: Heme-induced trained immunity protects against sepsis
14.15   Vicky Matzaraki: GWAS of trained immunity – role of KDM4
14.30   Christine Stabell-Benn: Non-specific protective effects of vaccination
15.00   Nigel Curtis: MIS-BAIR study of BCG vaccination
15.30   Break
16.00   Keynote Prof. Michael Skinner: trans-generational transmission of traits
16.45   Prizes and farewell

Need more info? Contact us

Marjolijn Klomp-Kooi MSc
Project Manager

+31 (0)6 29 01 16 73

Abstract/poster submission

Deadline abstract submission: September 15, 2019. Oral presentations will be chosen from the submitted abstracts, and a ‘Best Oral Presentation Prize’ and ‘Best Poster prize’ will be awarded.

read more

Abstract/poster submission

Deadline abstract submission: September 15, 2019
Oral presentations will be chosen from the submitted abstracts, and a ‘Best Oral Presentation Prize’ and ‘Best Poster prize’ will be awarded.

Link to the online abstract submission

Note: if you are already registered for this symposium or have registered with Radboudumc Health Academy before, click 'logon' (if necessary choose: Forgot you password).

Please use the New Frontiers in Innate Immune Memeroy abstract format. You can download the abstract format here.

To facilitate the submission process and the subsequent follow up process, please consider the following guidelines and deadlines mentioned.

Abstract format:
  • 350 words font size 11 
  • headings: background, aim, methods, results and discussion
  • figures allowed (max 2)
  • no references
Presentation type:
  • oral
  • poster
  • both