Raphaël Duivenvoorden, theme Renal disorders, and colleagues, looked at the immune response of patients admitted to the hospital with a SARS-CoV-2 infection. They observed that monocytes, play an important role in the first line of defense against the coronavirus. Therefore, they investigated the effect of hydroxychloroquine on these cells. They have discovered an as yet unknown effect of hydroxychloroquine. It inhibits trained immunity, which is important in the first line of defense against infections. That is why they expect hydroxychloroquine to have no beneficial effect on the immune response in a SARS-CoV-2 infection.
They have published these findings in MedRxiv: Hydroxychloroquine inhibits trained immunity - implications for COVID-19 - Nils Rother, Cansu Yanginlar, Rik G.H. Lindeboom, Siroon Bekkering, Mandy M.T. van Leent, Baranca Buijsers, Inge Jonkman, Mark de Graaf, Marijke Baltissen, Lieke A. Lamers, Niels P. Riksen, Zahi A. Fayad, Willem J.M. Mulder, Luuk B. Hilbrands, Leo A.B. Joosten, Mihai G. Netea, Michiel Vermeulen, Johan van der Vlag, Raphaël Duivenvoorden. Articles in MedRxiv are not peer-reviewed.
Raphaël explained on the Dutch TV (NPO Op 1) about this research. You can wath this here.
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