The study is meant to reveal whether a shorter treatment using a new combination of four different antibiotics could be as effective as the regular, longer treatment for tuberculosis (TB).If this research, named SimpliciTB, turns out successful, the treatment period for drug-sensitive tuberculosis could be reduced from six to four months, and the treatment of drug-resistant tuberculosis could go down from 18-24 months to six months.
Shorter treatmentA shorter treatment of TB brings several significant advantages. If the patient is cured faster, the period of contagiousness to others will also be shorter, which will also decrease the chance of the disease spreading. Additionally, it helps increase the patients’ compliance. The access to hospitals and proper medical care in the countries where TB occurs is often limited, which frequently puts the therapy compliance at stake in longer-term treatments. The shorter the treatment, the better the chances are of a patient finishing it. In the case of TB, completing the entire course of treatment is crucial. Mediocre therapy compliance can result in an increased resistance of the bacteria.
Radboud university medical center’s roleThe study is a global initiative of the TB Alliance. The Sub-Saharan African part of the study is carried out by PanACEA, a consortium of 16 institutes in 11 countries, coordinated by Martin Boeree and Rutger Spoor from the department of Pulmonary Diseases at Radboud university medical center. PanACEA received 12 million euros for this study, of which 1.6 million euros is made available to Radboud university medical center. Radboud university medical center takes on the management and medical monitoring and will work on the research capacity development of the African partners.
Capacity developmentThe continued development of African clinical research centers is a priority of the PanACEA consortium. Its aim is to get these centers to a higher level and keep them there and to have their clinical research meet the highest quality requirements, such as those of the European Medicines Agency (EMA) and the U.S. Food and Drug Administration (FDA). This will put African centers in a position in which they will be able to lead future research. Aspects of capacity development include the development of infrastructure, admission facilities, laboratories and drugstores, but also the scientific support of PhD candidates and postdocs.
About tuberculosisTuberculosis is a prevalent infectious disease. About 2.3 billion people around the world have a latent infection, and 10 million new patients develop the active disease each year. Tuberculosis is caused by the Mycobacterium tuberculosis bacteria. These bacteria penetrate the cells and can become encased there. During this process, the tissue can get damaged, which leads to the disease. Tuberculosis generally affects the lungs but can also affect other parts of the body.
Related news items
Merel Ritskes-Hoitinga has been appointed honorary Skou professor at Aarhus University17 October 2019
Merel Ritskes-Hoitinga has been appointed honorary Skou Professor at the Dept. of Clinical Medicine, at Aarhus University. The aim is to introduce new perspectives to teaching, strengthen relations with leading research units abroad and establish joint research projects and funding applications.read more
A personal touch of Maroeska te Loo15 October 2019
In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t. This week: Maroeska te Loo.read more
KWF Roadshow 11 November 201910 October 2019
In which way(s) can KWF provide optimal support to oncological research and care? How can we maximize impact on our investments? These questions are pivotal in Ambition 2030: the vision that KWF developed in close cooperation with stakeholders in the oncological field.read more
More than 3000 visitors at Open Day RIHS10 October 2019
On Sunday 6 October RIHS organized an Open Day in the Weekend of Science (“Weekend van de Wetenschap”) with special guest and television presenter Klaas van Kruistum. More than 3000 visitors became a health scientist for one day and discovered how special healthcare research is.read more
‘Smart shirt’ can accurately measure breathing and could be used to monitor lung disease3 October 2019
Denise Mannée and colleagues are developing Hexoskin, a smart shirt that can measure breathing in people. It can reliably measure breathing in healthy people while carrying out activities. This means they can now test out the smart shirts with patients who have COPD.read more