Annemiek van Spriel full professor
Scientific interests include immunology at the cellular and molecular level with a major focus on the plasma membrane organization of antigen-presenting cells. Tetraspanin proteins coordinate the spatial organization of specific immunoreceptors and signaling molecules into 'tetraspanin microdomains'. We discovered that tetraspanins are critically involved in immune cell function, including antigen presentation, proliferation and antibody production. The aim of our research is to unravel the molecular mechanisms that underlie tetraspanin microdomain function in immune cells in relation to the development of malignant disease.
Dr. Annemiek van Spriel is a tenured senior scientist at the Department of Tumor Immunology. She pursued a long-term Post-Doctoral Fellowship in the Leukocyte Membrane Laboratory of Ass. Prof. Mark Wright (Burnet Institute, Melbourne, Australia). In 2004, she joined the Tumor Immunology Department in the NCMLS where she obtained Grants from The Netherlands Organization for Scientific Research (NWO) and the Dutch Cancer Society (KWF) to establish her own research line that is focused on investigating tetraspanins in immune cells in relation to the development of cancer.
The underlying molecular mechanisms of PKC signaling in B cells are only partially resolved. Malou Zuidscherwoude and Vera Dunlock, group of Annemiek van Spriel, now discovered that in response to B cell receptor stimulation, PKC was specifically recruited to plasma membrane microdomains containing tetraspanin CD53. Click here for the full text of the article.
In 2012, she has been awarded the prestigious NWO-Vidi Grant for her work on tetraspanin proteins in the immune system. In 2016, Annemiek van Spriel has been awarded the ERC consolidator grant (2M Euro) to investigate Tetraspanin proteins on tumour cells.