People Camiel Rosman PRECIES study

PRECIES study

Feasibility of preoperative staging with USPIO MRI in patients with resectable esophageal carcinoma (PRECIES study).

Research group leader

Camiel Rosman MD PhD

+31 (0)24 366 80 86
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Aims

Staging of esophageal carcinoma after neoadjuvant chemoradiotherapy (nCRT) is currently inadequate because of the low accuracy of current imaging techniques.

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Aims

Staging of esophageal carcinoma after neoadjuvant chemoradiotherapy (nCRT) is currently inadequate because of the low accuracy of current imaging techniques. With accurate staging of lymph node metastases after nCRT, it is possible to personalize the treatment strategy. For example, preclude unnecessary lymph node dissections by patients without lymph node metastases (70% of the patients).
 
MRI with ultrasmall superparamagnetic iron oxide nanoparticles (USPIO, ferumoxtran-10) has been reintroduced to detect metastatic lymph nodes in prostate cancer. The aim of this proof of concept study is to assess the feasibility of USPIO-MRI to detect loco-regional lymph node metastases in patients with esophageal cancer.
 

Research within MITeC

In this study, the MRI scan is made in the MITeC OR with controlled mechanical ventilation after induction of anesthesia, prior to surgery.

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Research within MITeC

In this study, the MRI scan is made in the MITeC OR with controlled mechanical ventilation after induction of anesthesia, prior to surgery. During controlled prolonged apneu a four-minute iron-sensitive MRI acquisition allows a clinically relevant spatial resolution to study the feasibility of USPIO-MRI without motion artefacts.
 

Team


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