Christian Gilissen associate professor
Christian Gilissen studied computer sciences at the Radboud University Nijmegen after which he started his PhD in 2006 at the department of Human genetics of the Radboud University Medical Hospital in Nijmegen under the supervision of Prof. Dr. Ir. Joris Veltman and Prof. Dr. Han Brunner. He obtained his PhD in 2012 on “Disease gene identification through Next Generation Sequencing”, for which he received the Dutch bioinformatics young researcher award. After his PhD he continued his work in Nijmegen as a post-doctoral researcher and worked for 3 months at the Computational Biology Group at the Charité-Universitätsmedizin Berlin, under supervision of Prof. Peter Robinson. In 2013 he received a personal Veni grant from the Dutch Organization for Scientific Research to develop novel methodologies based on normal variation in order to predict gene function and the impact of mutations. At the European Society of Human genetics meeting in 2014 he received the international Isabelle Oberlé award for his work on genome sequencing of patients with intellectual disability that was published in Nature. His work was also rewarded by the young investigator award of the Dutch Society of Human Genetics in that same year. From 2017 onwards he became the head of bioinformatics within the division of genome diagnostics and an associate professorship in the division of within the department of Human Genetics in Nijmegen. His most recent work involved the large-scale analyses of patients with intellectual disabilities and the characteristics of genome-wide de novo mutations. In June 2017 he obtained a prestigous Vidi research grant on the integration of exome sequencing and metabolomics.
Personal prizes & awards national & international
- Dutch society of human genetics (NVHG) Young Investigator award 2014
- European Society of Human Genetics, Isabelle Oberlé Award for an outstanding presentation in the field of intellectual disability 2014
- European Journal of Human Genetics, Nature Citation Award, 1st prize most cited article 2014
- Nominee European Society of Human Genetics Young Investigator award
- Dutch Bioinformatics (NBIC) Young Investigator award 2012
- European NGS meeting, Best presentation award
- 06/2017 - 06/2022 Board member European Society of Human Genetics
- 02/2017 - 01/2020 Advisory board of the Clinical Genome Center Denmark.
- 01/2017 - 01/2020 Member Flanders Research Foundation (FWO) expert panel (med2)
- 04/2016 - current Advisory committee (AAR) of the University of Applied sciences Arnhem/Nijmegen for Bioinformatics education
- 04/2015 - current Advisory board bioinformatics for Genomics England
- 11/2014 - 11/2016 Member American Society of Human Genetics (ASHG) program committee
- 06/2016 – current Director of the European school of Genetic Medicine - Course in “Medical genetics and Next Generation Sequencing", Bertinoro de Romagna - Italy
- 09/2012 – current Course on ”Genomic resequencing: variant detection and interpretation in a diagnostic context", Rotterdam
- 05/2011 - 05/2015 Co-organizer of the European school of Genetic Medicine - Course in Next Generation Sequencing, Bertinoro de Romagna - Italy
Field of studyHuman Genetics
- Wiel L, Baakman C, Gilissen D, Veltman JA, Vriend G and Gilissen C
MetaDome: Pathogenicity analysis of genetic variants through aggregation of homologous human protein domains. Hum Mutat, 2019 May 22.
- Goldmann JM*, Seplyarskiy VB*, Wong WSW, Vilboux T, Neerincx PB, Bodian DL, Solomon BD, Veltman JA, Deeken JF, Gilissen C¥, Niederhuber JE¥.
Germline de novo mutation clusters arise during oocyte aging in genomic regions with high double-strand-break incidence. Nat Genet. 2018 Apr;50(4):487-492.
- Lelieveld SH, et al. Spatial Clustering of de Novo Missense Mutations Identifies Candidate Neurodevelopmental Disorder-Associated Genes. Am J Hum Genet. 2017 Sep 7;101(3):478-484. doi: 10.1016/j.ajhg.2017.08.004. Epub 2017 Aug 31. PMID: 28867141
- Wiel L, et al. Aggregation of population-based genetic variation over protein domain homologues and its potential use in genetic diagnostics.
Hum Mutat. 2017 Nov;38(11):1454-1463. doi: 10.1002/humu.23313. Epub 2017 Aug 31. PMID: 28815929
- Vulto-van Silfhout AT, et al. Quantification of Phenotype Information Aids the Identification of Novel Disease Genes. Hum Mutat. 2017 May;38(5):594-599. PMID: 28074630.
- Lelieveld SH, et al. Meta-analysis of 2,104 trios provides support for 10 new genes for intellectual disability. Nat Neurosci. 2016 Aug 1. PMID: 27479843.
- Goldmann JM, et al. Parent-of-origin specific signatures of de novo mutations. Nat Genet. 2016 Jun 20. PMID: 27322544.
- Vissers LE, et al. Genetic studies in intellectual disability and related disorders. Nat Rev Genet. 2015 Oct 27. PMID: 26503795.
- Lelieveld SH, et al. Novel bioinformatic developments for exome sequencing. Hum Genet. 2016 Apr 13. PMID: 27075447
- Acuna-Hidalgo R, et al. Post-zygotic Point Mutations Are an Underrecognized Source of De Novo Genomic Variation. Am J Hum Genet. 2015 Jun 3. PMID: 26054435.
- Lelieveld SH, et al. Comparison of Exome and Genome Sequencing Technologies for the Complete Capture of Protein Coding Regions. Hum Mutat. 2015 May 14. PMID: 25973577.
- Gilissen C, et al. Nature. 2014 Jul 17;511(7509):344-7. PMID: 24896178.
- Neveling K, et al. A Post-Hoc Comparison of the Utility of Sanger Sequencing and Exome Sequencing for the Diagnosis of Heterogeneous Diseases. Hum Mutat. 2013 Dec;34(12):1721-6. PMID: 24123792.
- van Bon BW, et al. Cantú Syndrome Is Caused by Mutations in ABCC9. Am J Hum Genet. 2012 May 16. PMID: 22608503.
- Gilissen C, et al. Exome Sequencing Identifies Truncating Mutations in Human SERPINF1 in Autosomal-Recessive Osteogenesis Imperfecta. Am J Hum Genet. 2011, PMID: 21353196.
- Gilissen C, et al. Unlocking Mendelian disease using exome sequencing. Genome Biol. 2011 Sep 14;12(9):228. PMID: 21920049. IF = 6.63
- Vissers LE, et al. A de novo paradigm for mental retardation. Nat Genet. 2010 Dec;42(12):1109-12. PMID: 21076407.
- Gilissen C*, et al. Exome Sequencing Identifies WDR35 Variants Involved in Sensenbrenner Syndrome. Am J Hum Genet. 2010 Sep 10;87(3):418-23. PMID: 20817137.
- Hoischen A*, et al. De novo mutations of SETBP1 cause Schinzel-Giedion syndrome. Nat Genet. 2010 Jun;42(6):483-5. PMID: 20436468.
- Nikopoulos K, et al. Next-generation sequencing of a 40 Mb linkage interval reveals TSPAN12 mutations in patients with familial exudative vitreoretinopathy. Am J Hum Genet. 2010 Feb 12;86(2):240-7. PMID: 20159111.
- Hoischen A, et al. Massively parallel sequencing of ataxia genes after array-based enrichment. Hum Mutat. 2010 Apr;31(4):494-9. PMID: 20151403.
- Dutch science foundation (NWO) Vidi grant “Integrating Metabolomics and Genomics for understanding human Disease". €800,000 (10/2017 - 10/2022)
- Junior Principle Investigator, Radboud UMC. €150,000 (05/2015 – 05/2018)
- RIMLS PhD grant “A holistic approach to the analysis of genetic variation in patients". €250,000 (09/2015 – 09/2018)
- Province of Gelderland, Robust investment impulse", “Compute infrastructure for Clinical genome sequencing”. €1,845,000 (03/2014)
- Dutch science foundation (NWO) Veni grant “Population variation for genome interpretation". €250,000 (01/2014 – 03/2017)
- ZONMW Technology hotel grant: “Uncovering hidden genetic variation in the human genome.” € 30,000 (01-01-2018 – 01-01-2019)
- BMS31, Omics data analysis for systems biology - Biomedical Sciences (MSc)
- Research Projects - Medicine/Biomedical Sciences (BSc)
- MOL055, Molecular basis of diseases - Medical biology (BSc)
- MM3CF Molecular mechanisms of disease - Biomedical Sciences (MSc)
- MMST Omics data analysis and interpretation
In the news
BNR interview about finding 10 new genes (publication 1 on the list key publications):http://www.bnr.nl/radio/wetenschap-vandaag/10308899/met-statistiek-nieuwe-genen-ontdekken
About publication 2 on the list (NL):http://www.bnr.nl/player/archief/20160621185230300
About publication 5 on the list (EN):https://www.sciencedaily.com/releases/2015/06/150606204102.htm
Science webinar (EN):http://webinar.sciencemag.org/webinar/archive/exome-sequencing-today%E2%80%99s-lab
Interview for computer science education(NL):
Germline de novo mutation clusters arise during oocyte aging6 March 2018
Publication in Nature genetics by Jakob Goldmann and Christian Gilissen, resp. themes Reconstructive and regenerative medicine and Mitochondrial diseases.read more