Geert van den Bogaart
Geert van den Bogaart is a biochemist and cell biologist studying intracellular membrane trafficking. Research interests include the molecular mechanisms controlling cytokine release and the processing of antigen by antigen presenting cells, in particular dendritic cells. Geert’s group also develops new tools to study intracellular membrane trafficking pathways. More information can be found on the homepage of his laboratory: Molecular Immunology lab
After obtaining his PhD in biochemistry with distinction (2008, University of Groningen, the Netherlands), Geert van den Bogaart worked as a postdoctoral fellow in neurobiology at the Max Planck Institute for Biophysical Chemistry (2008-2012, Göttingen, Germany). In 2012, Geert started his own group at the department of Tumor Immunology (Radboud University Medical Center, Nijmegen) funded by a Hypatia tenure track fellowship. His group, the Membrane Trafficking in Immune Cells Laboratory, studies membrane trafficking in immune cells. Geert is the recipient of the Dutch Society Prize for Young Talent (2004), the H.G.K.Westenbrink Prize (2009), the Heineken Young Scientist Award for Biochemistry and Biophysics (2012), a Hypathia Tenure Track Grant from the Radboud University Medical Center (2912), a Starting Grant from the European Research Council (2012), a Career Development Award from the Human Frontier Science Program (2013) and a VIDI grant from the Netherlands Organisation for Scientific Research (2015).
Membrane trafficking mechanisms underlying T cell activation. Polarized trafficking of cytokines and membrane receptors to the immunological synapse between dendritic cells and T cells. The molecular pathways of cytokine secretion. The molecular mechanisms for the uptake and subsequent degradation of foreign antigen by dendritic cells. The antigen-specific maturation steps of endosomes and phagosomes. The assembly of the NADPH-oxidase NOX2 on antigen containing compartments The rerouting of intracellular membrane trafficking pathways upon antigen recognition by dendritic cells.