People Hendrik Marks

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Hendrik Marks PhD

+31 (0)24 361 05 61
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Hendrik Marks assistant professor

The aim of my research group is to further define the ground state and to decipher regulatory mechanisms that maintain ESCs in the ground state.

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Hendrik Marks assistant professor

Embryonic stem cells (ESCs) are derived from the inner cell mass (ICM) of the early embryo and are widely used as in vitro model to study pluripotency and embryonic development. Recent advances in stem cell technology enabled the derivation of mouse ESCs in defined serum-free medium containing 2 kinase inhibitors (2i), so-called “ground state” pluripotent ESCs. The inhibitors are thought to maintain stemness by blocking the signalling activity of Erk and Gsk3. Information on signal transduction, transcriptional networks and epigenetic mechanisms acting in ground state pluripotent cells is scarce.The aim of my research group is to further define the ground state and to decipher regulatory mechanisms that maintain ESCs in the ground state. Current projects include: i) unravel the mode of action of the 2 kinase inhibitors in ground state pluripotency by state-of-the-art (phospho)proteomics on signaling pathways and nuclear factors; ii) decipher regulatory transcription factor networks and epigenetic mechanisms acting to maintain and to exit the ground state by genome-wide bisulfite sequencing and ChIP-seq; iii) use single cell RNA-Seq profiling to determine the role of (transcriptional) heterogeneity.

Personal prizes & awards National & international

  • 2017: Van Gogh grant for collaborative research with INRA
  • 2014 - 2015: Hypatia talent development career track for young groupleaders
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Personal prizes & awards National & international

  • 2017: Van Gogh grant for collaborative research with INRA (2017)
  • 2014 - 2015: Hypatia talent development career track for young groupleaders
  • 2013 - 2018: VIDI personal grant: 800k euro personal grant to investigate pluripotency
  • 2013: Nomination Radboud Science Award (2013)
  • 2013: Best paper of RIMLS institute
  • 2005: Educational PhD certificate
  • 2002 - 2005: Travel Grants: Stichting LEB Fonds 2.5k euro for meetings in USA/ Canada
  • Various of my publications were accompanied by extensive editorials, and highlighted in national newspapers

Additional functions

  • Member of DB examination committee Biowetenschappen of Radboud University Nijmegen (2016 - present)
  • Gecommitteerde HAN Applied University Arnhem/Nijmegen (2017 - present)
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Additional functions

  • Member of DB examination committee Biowetenschappen of Radboud University Nijmegen (2016 - present)
  • Gecommitteerde HAN Applied University Arnhem/Nijmegen (2017 - present)
  • Co-coordinator Master Specilisation Medical Epigenomics of Medical Biology master of Radboud University Nijmegen (2015 - present)
  • Member of Numerus Fixus committee of Biology Bachelor Radboud Univerisity Nijmegen (2017 - present)
  • Member of NWO-CW studygroup Nucleinezuren

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Field of study

Molecular Biology

Radboud Institute for Molecular Life Sciences

Our main aim is to achieve a greater understanding of the molecular mechanisms of disease. By integrating fundamental and clinical research, we obtain multifaceted knowledge of (patho)physiological processes. read more