Jan Koenderink is assistant professor in biochemical toxicology at the Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre.
Research interests include molecular interaction of membrane transport proteins and their ligands (substrates and inhibitors). Current projects are focused on the molecular interaction of digitalis-like compounds with the sodium pump (Na,K-ATPase) and multidrug resistance proteins (ABC transporters) (VIDI 2008). In addition the interaction between membrane transporters and novel and existing human drugs, as well as the multidrug resistance transport proteins of the plasmodium parasite are investigated. The studies include the expression of recombinant transport proteins and their biochemical and pharmacodynamic characterization.
Our main aim is to achieve a greater understanding of the molecular mechanisms of disease. By integrating fundamental and clinical research, we obtain multifaceted knowledge of (patho)physiological processes.