Regulation of epithelial calcium transport
This research group works on the regulation of epithelial calcium transport, with a fundamental focus on the electrophysiological analysis combined with the biochemistry of ion channels and cell signaling.
Characterization of the structure-function relationship of epithelial ion channels. read more
CharacterizationThrough uniquely synergizing cutting-edge (bio)chemical and biophysical technologies, we aim to deliver detailed insight into TRPV (vanilloid subfamily) channels and unravel structural domains essential for channel function. A high-resolution structure aids in unravelling the pathogenicity of specific disease variants and can provide detailed insight into the actions of pharmacological compounds, to ultimately support drug development programs.
Understanding the molecular mechanisms involved in renal calcium handling and kidney stone formation. read more
UnderstandingThe urinary calcium concentration is an important factor in kidney stone formation, and it is evident that avoidance of new crystal deposits should be the prime target site in order to prevent recurrence. Here, we focus on gaining fundamental knowledge on the related process of how perturbations in tubular calcium transport induce kidney stone formation. In addition, we aim to develop of a new molecular entity with a unique mode of action that might in the future be used for effective treatment of kidney stones.
Radboudumc Technology Center Microscopic Imaging Center
The Microscopic Imaging Center offers access to both standard and innovative advanced microscopy infrastructure and applications including technical operator-assistance and in-depth microscopic imaging knowledge.read more