Joost Drenth full professor

Joost PH Drenth is a Gastroenterologist  and interested in polycystic liver disorders.  His research program centers on achieving a comprehensive molecular understanding of human gastrointestinal diseases. He is mainly focused on polycystic liver disease (PLD) which is characterised by massively enlarged liver that can grow to >6 times its original size. We have designed a  translational research program, with a clear focus on the elucidation of pathogenesis and development of novel medical treatment options. The final goal is discovery novel paradigms for effective treatment of patients. We have taken an approach that begins with disease gene discovery through positional cloning to understand the genetic bases for the diseases, followed by functional studies to understand cellular pathogenesis.  Our current projects include a clinical tract that aims to test new compounds for PLD in human patients. Our experimental tract aims to identify new identification of key intracellular signalling pathways in PLD by identifying novel genetic causes.
People Joost Drenth

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Joost Drenth MD PhD

+316 29 50 18 92
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Joost Drenth full professor

Joost PH Drenth is a Gastroenterologist and interested in polycystic liver disorders. His research program centers on achieving a comprehensive molecular understanding of human gastrointestinal diseases.

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Field of study

Gastroenterology

Radboud Institute for Molecular Life Sciences

Our main aim is to achieve a greater understanding of the molecular mechanisms of disease. By integrating fundamental and clinical research, we obtain multifaceted knowledge of (patho)physiological processes. read more

Research group Polycystic liver disease

Joost Drenth's group aims to discover novel paradigms for effective treatment of patients. Our strategy starts with disease gene discovery followed by functional studies to understand cellular pathogenesis. The main focus is polycystic liver disease, a rare inherited liver disorder.

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