People Marieke Coenen

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Marieke Coenen PhD

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Marieke Coenen associate professor

Dr. Coenen's research entails population-based gene-finding studies, construction of genetic prediction models, and cost-effectiveness analysis of pharmacogenetic tests.

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Marieke Coenen associate professor

My research group performs pharmacogenetic research, from gene-finding to clinical implementation, with the aim to optimise treatment for the individual patient. I started my group on pharmacogenetics focussing on gene-finding in rheumatoid arthritis, for which I set up a productive international collaboration. I led the first genome-wide association analysis for anti-TNF treatment outcome (PMID:23233654) and the first large-scale genetic study showing how proxy measures for standard clinical outcomes can successfully be applied (PMID: 25114059). I have since extended my pharmacogenetic studies to other disorders, including psoriasis, inflammatory bowel disease (IBD), and childhood osteosarcoma.
In addition to my work on gene-finding, I aim to push the uptake of pharmacogenetics into clinical care. For this, I led the world-wide largest randomized controlled trial for cost-effectiveness of thiopurine-S-methyltransferase genotyping prior to thiopurine treatment in IBD (PMID:26072396). I currently co-supervise a similar multicentre study in psychiatry investigating the cost-effectiveness of pharmacogenetic testing prior to tricyclic anti-depressants treatment.
I am also responsible for the diagnostic pharmacogenetic testing at the Radboudumc.




 

Personal prizes & awards national & international

  • 2006: VENI grant on pharmacogenetics of anti-TNF treatment

Additional functions


Education

  • Medical Biology, Univeristy of Utrecht
  • PhD department of Pediatrics of the Radboud university medical centre (2003). Subject: The assembly of the human oxidative phosphorylation system.
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Education

  • She studies Medical Biology at the University of Utrecht
  • She followed a PhD at the department of Pediatrics of the Radboud University Medical Centre
  • She started a postdoc at the department of Human Genetics

Field of study

Human Genetics, pharmacogenetics

Radboud Institute for Health Sciences

Ideally, every procedure in clinical practice and public health should take place based on proof, instead of intuition or 'experience'. Our aim is to innovate and personalize healthcare and public health. read more

Research group Pharmaco­genomics

Marieke Coenen's research group entails population-based gene-finding studies to identify genes predicting treatment outcome.

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