People Marieke Voet Perfusion measurements in pediatric kidney transplantation

Perfusion measurements in pediatric kidney transplantation

This research group is enhancing knowledge of the hemodynamic responses after pediatric kidney transplantation with a living, adult donor.

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Perfusion measurements in pediatric kidney transplantation

This research group is enhancing knowledge of the hemodynamic responses after pediatric kidney transplantation with a living, adult donor. Besides Magnetic Resonance Perfusion imaging (MRP), they aim to provide a non-invasive monitoring tool aiding in post-operative treatment protocols, using Ultrasound (US) or biomarkers.
 

Research group leader

Marieke Voet MSc

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Aims of this research group

  • Creating more insight
  • Investigating reliability
  • Defining a pharmacokinetic model
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Aims of this research group

  • Create more insight in the hemodynamic changes surrounding a pediatric kidney transplantation with a living donor by measuring graft perfusion with MRP - Arterial Spin Labeling (ASL).
  • Investigate the reliability of a non-invasive monitor for surveillance of donor kidney perfusion in children using transabdominal ultrasound. Additionally, kidney specific serum and urine biomarkers will be observed. If found reliable, these monitors can be used to steer postoperative treatment protocols in the future in order to reduce loss of renal graft mass and improve long term graft function.
  • Define a pharmacokinetic model for adult sized kidney transplantation in children. In addition DNA analysis of medication-metabolism specific enzymes will be done of donor, recipient and their parents for interpretation of pharmacokinetic differences and biomarkers after living donor kidney transplantation.

Research within MITeC

All kidney donations will be performed in our Hybrid-OR. Intra-operative flow is measured with US and kidney perfusion is measured in the adjacent room with MR ASL, all at the MITeC facility.

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Radboud Institute for Health Sciences

Ideally, every procedure in clinical practice and public health should take place based on proof, instead of intuition or 'experience'. Our aim is to innovate and personalize healthcare and public health. read more