Perfusion measurements in pediatric kidney transplantation
This research group is enhancing knowledge of the hemodynamic responses after pediatric kidney transplantation with a living, adult donor.read more
Perfusion measurements in pediatric kidney transplantationThis research group is enhancing knowledge of the hemodynamic responses after pediatric kidney transplantation with a living, adult donor. Besides Magnetic Resonance Perfusion imaging (MRP), they aim to provide a non-invasive monitoring tool aiding in post-operative treatment protocols, using Ultrasound (US) or biomarkers.
Aims of this research group
- Create more insight in the hemodynamic changes surrounding a pediatric kidney transplantation with a living donor by measuring graft perfusion with MRP - Arterial Spin Labeling (ASL).
- Investigate the reliability of a non-invasive monitor for surveillance of donor kidney perfusion in children using transabdominal ultrasound. Additionally, kidney specific serum and urine biomarkers will be observed. If found reliable, these monitors can be used to steer postoperative treatment protocols in the future in order to reduce loss of renal graft mass and improve long term graft function.
- Define a pharmacokinetic model for adult sized kidney transplantation in children. In addition DNA analysis of medication-metabolism specific enzymes will be done of donor, recipient and their parents for interpretation of pharmacokinetic differences and biomarkers after living donor kidney transplantation.
Research within MITeCAll kidney donations will be performed in our Hybrid-OR. Intra-operative flow is measured with US and kidney perfusion is measured in the adjacent room with MR ASL, all at the MITeC facility.
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